DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPT2 and CPT1C

DIOPT Version :9

Sequence 1:	NP_647756.1	Gene:	CPT2 / 38355	FlyBaseID:	FBgn0035383	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_024307116.1	Gene:	CPT1C / 126129	HGNCID:	18540	Length:	836	Species:	Homo sapiens

Alignment Length:	706	Identity:	189/706 - (26%)
Similarity:	310/706 - (43%)	Gaps:	124/706 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GQHYQYLQCSKLPTLY-FQRSLPRLPIPLLENSCRRFLEATKPLLSPAEQAQTQQTVEQF--RQG 86
            |:|         |.|: :||||||.|:|.::::.|::||:.:|:||..:...|....::|  .|.
Human   159 GRH---------PMLFSYQRSLPRQPVPSVQDTVRKYLESVRPILSDEDFDWTAVLAQEFLRLQA 214

  Fly    87 IGMELHAKLKSHDAENKHTSYISQPWFD-MYLADRAPLPLNYNPLLVMKSDARPEYQQQVVRATN 150
            ..::.:.:|||..|.|    |:|..|.: :||..|.||.:|.|           .|....:..|.
Human   215 SLLQWYLRLKSWWASN----YVSDWWEEFVYLRSRNPLMVNSN-----------YYMMDFLYVTP 264

  Fly   151 LIISSLRFWRSLQADLLEPEVYHMNAKKSDTSSYR--RWMK-----------VAP----KAFATY 198
            ..:.:.|...::.|.||    |.....:.:....|  :|::           |.|    .|....
Human   265 TPLQAARAGNAVHALLL----YRHRLNRQEIPPVRGPQWVRDGGVVLWPLGHVGPGRQLTAHGFL 325

  Fly   199 ASYAFKAFPLDMSQYNRLFGTSRIPRIGKDELVQSPDAKHILVMRRGHMYAVNVLDSSGYIESPS 263
            .:......||..:||.::|.|:|||.:.||.:....|::|:.|..||..:.:.. .|...:.||.
Human   326 QTLLMGMRPLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRMGT-HSRNSLLSPR 389

  Fly   264 VILGRLRAVLKLDADREAASVP----LGVLTSGQRDEWAKTRQHFVSNTKNADLLEREVDAALFC 324
            .:..:.:.:|    |..:.:.|    |..||:..|..||:.|...  .|:.|:.|| .|:.|.|.
Human   390 ALEQQFQRIL----DDPSPACPHEEHLAALTAAPRGTWAQVRTSL--KTQAAEALE-AVEGAAFF 447

  Fly   325 VCLDGEEDGVFNENQQEPLLKH---LLAGKAQNRWFDKSISLLISADGTTAINFEHSWGDGVAVL 386
            |.||.|..|:..|:....|..:   ||||:..:||||||.:|::.::|...::.||||.|    .
Human   448 VSLDAEPAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWAD----C 508

  Fly   387 RYFNELYKDTLK----QPFVSTETVHTPAEGDFSNVRP--INFEIDDATKSAVSEAYNKNASIVD 445
            .....:::.||.    |...||:. |.....|.:..:|  :.:::.|...|::|.|......:.:
Human   509 PISGHMWEFTLATECFQLGYSTDG-HCKGHPDPTLPQPQRLQWDLPDQIHSSISLALRGAKILSE 572

  Fly   446 NLDMNVLKYPHINKPTCKQYGLSPDSIIQLSFQLAYRQAYSGYVGSYESCSTSAFRHGRTETMRP 510
            |:|.:|:.:....|...::..||.||.||::.|||:.:....:..:|||..|..|..|||||:|.
Human   573 NVDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRS 637

  Fly   511 CTNATRDFCEAILQPERSKPSAGEL-RAMIDNCSKVHGQLTKEAAMGQGFDRHLFALR------- 567
            ||....:|..|:...|::.|....| |..:|.    |..|.|.|..|||.|||||||.
Human   638 CTREACNFVRAMEDKEKTDPQCLALFRVAVDK----HQALLKAAMSGQGVDRHLFALYIVSRFLH 698

  Fly   568 ---------HTAQ----KEGIPIPD--LYETEAYKRINNNIISTSTLGSDALLAGSFGPVVKNGF 617
                     |:.|    ...||:..  |::...|.    :.:|:         .|.|||...:|:
Human   699 LQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYP----DYVSS---------GGGFGPADDHGY 750

  Fly   618 GIGYSIQNDFAGAIVTTYKNQADGKVFIDS------LESAFDKICAVIQQSSSSKK 667
            |:.|....|   .::|.:.:........||      :|.|...:.::.|.....|:
Human   751 GVSYIFMGD---GMITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFKR 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPT2	NP_647756.1	Carn_acyltransf	45..655	CDD:279140	180/671 (27%)
CPT1C	XP_024307116.1	CPT_N	1..46	CDD:318644
CPT1C	XP_024307116.1	Carn_acyltransf	171..788	CDD:307070	179/668 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920