Protein Alignment CPT2 and CHAT

DIOPT Version :10

• Sequence 1: NP_647756.1
• Gene: CPT2 / 38355
• FlyBaseID: FBgn0035383
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_065574.4
• Gene: CHAT / 1103
• HGNCID: 1912
• Length: 748
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 168/641 - (26%)
• Similarity: 294/641 - (45%)
• Gaps: 56/641 - (8%)

  Fly    42 QRSLPRLPIPLLENSCRRFLEATKPLLSPAEQAQTQQTVEQFRQ--GIGMELHAKLKSHDAENKH 104
            :..||:||:|.|:.:...:|:..:.|:|..:..::|..|:||..  |:|..|..||.  :.:.|.
Human   128 ESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLL--ERQEKT 190

  Fly   105 TSYISQPWF-DMYLADRAPLPLNYNPLLVMKSDARPEYQQQVVRATNLIISSLRFWRSLQADLLE 168
            .:::|:.|. ||||.:|..||:|.:|.::......|....|:..|.:||...|.:     ..||:
Human   191 ANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSY-----KALLD 250

  Fly   169 PEVYHMNAKKSDTSSYRRWMKVAPKAFATYASYAFKAFPLDMSQYNRLFGTSRIPRIGKDELVQS 233
            ......:..|...|..                      ||.|.||..||.:.|:|...:|.||..
Human   251 SHSIPTDCAKGQLSGQ----------------------PLCMKQYYGLFSSYRLPGHTQDTLVAQ 293

  Fly   234 -----PDAKHILVMRRGHMYAVNVLDSSGYIESPSVILGRLRAVLKLDADREAASVPLGVLTSGQ 293
                 |:.:|::|......:.::|:.:...: |...:..:||.::|:.::.:....|:|:|||..
Human   294 NSSIMPEPEHVIVACCNQFFVLDVVINFRRL-SEGDLFTQLRKIVKMASNEDERLPPIGLLTSDG 357

  Fly   294 RDEWAKTRQHFVSNTKNADLLEREVDAALFCVCLDGEEDGVFNENQQEPLLKHLLAG-----KAQ 353
            |.|||:.|...|.::.|.|.|:. ::..:..||||. ..||...:....|  .||.|     ...
Human   358 RSEWAEARTVLVKDSTNRDSLDM-IERCICLVCLDA-PGGVELSDTHRAL--QLLHGGGYSKNGA 418

  Fly   354 NRWFDKSISLLISADGTTAINFEHSWGDGVAVLRYFNELYKDTLKQPFVSTETVHTPAEGDFSNV 418
            |||:|||:..::..|||..:..|||..||:.:::....|.|...:.   |.:.:...:..:....
Human   419 NRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHVTQS---SRKLIRADSVSELPAP 480

  Fly   419 RPINFEIDDATKSAVSEAYNKNASIVDNLDMNVLKYPHINKPTCKQYGLSPDSIIQLSFQLAYRQ 483
            |.:.::.....:..::.:..|...||.|||..|.|:.:..|...|:...|||:.||::.|||:.:
Human   481 RRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYR 545

  Fly   484 AYSGYVGSYESCSTSAFRHGRTETMRPCTNATRDFCEAILQPERSKPSAGELRAMIDNCSKVHGQ 548
            .:...|.:|||.|...|:.||.:.:|..|.....|..|:...:.:.| |.|...::.:..:....
Human   546 LHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVP-ASEKLLLLKDAIRAQTA 609

  Fly   549 LTKEAAMGQGFDRHLFALRHTAQKEGIPIPDLYETEAYKRINNNIISTSTLGSDALLAGSFGPVV 613
            .|..|..|...|.||.|||..|:.....:|:::..|.|...|..::|||.:.:...:...:||||
Human   610 YTVMAITGMAIDNHLLALRELARAMCKELPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVV 674

  Fly   614 KNGFGIGYSIQNDFAGAIVTTY---KNQADGKVFIDSLESAFD--KICAVIQQSSS 664
            .||:|..|:.|.:.....::::   |..:..|......||..|  .:|:::..:.|
Human   675 PNGYGACYNPQPETILFCISSFHSCKETSSSKFAKAVEESLIDMRDLCSLLPPTES 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPT2	NP_647756.1	Carn_acyltransf	48..650	CDD:459926	161/617 (26%)
CHAT	NP_065574.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..89
		PHA03247	<27..138	CDD:223021	4/9 (44%)
		Carn_acyltransf	134..713	CDD:459926	161/616 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	727..748		1/4 (25%)