Protein Alignment Shab and Kcnc4

DIOPT Version :9

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_006502538.1
• Gene: Kcnc4 / 99738
• MGIID: 96670
• Length: 666
• Species: Mus musculus
• Alignment Length: 862
• Identity: 228/862 - (26%)
• Similarity: 334/862 - (38%)
• Gaps: 311/862 - (36%)

  Fly   293 PPEPFMIAQSKA---VNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRE---------------- 338
            ||....:.:..|   .:.::.|||||.|||....||..||.|||..|.:
Mouse    19 PPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGS 83

  Fly   339 ------------CTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAF 391
                        |                  |:||||||..|:.:||:|||||||...::|...|
Mouse    84 SGSSGGGGGGGGC------------------EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLF 130

  Fly   392 SDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQR----------------DEEEF- 439
            .::|.:||:||..:|.||...|.|.::      .:||..:.:.                ||.|.
Mouse   131 EEELTFWGIDETDVEPCCWMTYRQHRD------AEEALDIFESPDGGGGGAGPGDEAGDDERELA 189

  Fly   440 ---------------GEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNT--- 486
                           |.|.|..:|..:|.|.|.|.:|.||||:|..|:.||::|.....|.|
Mouse   190 LQRLGPHEGGSGPGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEA 254

  Fly   487 ------LPQLQHIDNGTP-------QDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLN 538
                  :.::..:.|.|.       :..|.|..:|.||:.|||||:::|....||...|.|..||
Mouse   255 FNIDRNVTEIHRVGNITSVRFRREVETEPILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLN 319

  Fly   539 IIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNS 603
            |||.:||||:::.:.|...:..|.   :||...::|.|.:|||||.||.||..||:.||.|||.|
Mouse   320 IIDFVAILPFYLEVGLSGLSSKAA---RDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRAS 381

  Fly   604 YKELGLLMLFLAMGVLIFSSLAYFAE---------KDEKDTKFVSIPETFWWAGITMTTVGYGDI 659
            ..|..||::|||:|||||:::.|:||         :....|.|.:||..||||.:||||:||||:
Mouse   382 TNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDM 446

  Fly   660 YPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSF 724
            ||.|..|.::|.:|.:.|||.||:|:|:|||||..:|...|.::|..|:|:
Mouse   447 YPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRK-------------- 497

  Fly   725 HHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDGNSTE 789
            .|:                           |:..:..:|..                      .:
Mouse   498 KHV---------------------------PRPPQLESPIY----------------------CK 513

  Fly   790 GESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFDNPNARQTSMMAMESY 854
            .|.||.|:..                                    ||..:|.||
Mouse   514 SEETSPRDST------------------------------------YSDTSPPAR---------- 532

  Fly   855 RREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVATATNASNA 919
               ::.::::::...:|            ||:                    |.||.:
Mouse   533 ---EEGVVERKRADSKQ------------NGD--------------------ANAVLS------- 555

  Fly   920 SNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQVALENLQNQRMDNLEQ 984
                          |.:|.|     |:|    |:.:..||.|...|||....:  :|::.
Mouse   556 --------------DEEGAG-----LTQ----PLALAPTPEERRALRRSGTRD--RNKKA----- 590

  Fly   985 DVPVEFECCFCTTKDFKEFTDAEGVISLPTSDFHKPICLEMRLAAAGRQAGAYGLLSPLPAPLPP 1049
                  ..||..:..  ::..|:|.:   .....|...|.....|||...|...|.|...:|.||
Mouse   591 ------AACFLLSAG--DYACADGSV---RKGCEKSRSLNNIAGAAGTSLGLSPLASRYSSPYPP 644

  Fly  1050 ----LHGPLLALPPPPP 1062
                |..|...|..|||
Mouse   645 RKLLLSPPFHPLTSPPP 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	45/134 (34%)
		BTB_2	309..408	CDD:280393	42/126 (33%)
		Ion_trans	501..700	CDD:278921	96/207 (46%)
		Ion_trans_2	613..696	CDD:285168	45/91 (49%)
Kcnc4	XP_006502538.1	Potassium_chann	1..29	CDD:314363	2/9 (22%)
		BTB_KCNC2_4	35..162	CDD:349722	47/150 (31%)
		Ion_trans	229..487	CDD:366146	108/260 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820