DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcnb2

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001091998.1	Gene:	Kcnb2 / 98741	MGIID:	99632	Length:	907	Species:	Mus musculus

Alignment Length:	862	Identity:	393/862 - (45%)
Similarity:	514/862 - (59%)	Gaps:	164/862 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 LQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEA 344
            |.|..|||..|: ||||..|.:||..:.||.|||||:.||||||||:|||.||||:||:|.|||:
Mouse     9 LNRKTSRSTLSL-PPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHES 72

  Fly   345 IVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCC 409
            ::|:||||:|.:|||||||||.:|:||||||||||||:::|||.|:|..:|:|||:||:||||||
Mouse    73 LLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCC 137

  Fly   410 QHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILF 474
            |.:|||:||.::||:|:|||::|:|:.|||....|.|.:|.||:||||||:|.||:::|::||||
Mouse   138 QARYHQKKEQMNEELRREAETMREREGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVSILF 202

  Fly   475 IVLSTIALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLN 538
            ||||||||:|||||:||..|. |.|.||.:||.||||||.|||:||:|||.:||:|||||||.||
Mouse   203 IVLSTIALSLNTLPELQENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLN 267

  Fly   539 IIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNS 603
            :|||||||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.|
Mouse   268 VIDLLAILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRS 331

  Fly   604 YKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKV 668
            |.|||||:||||||::|||||.:||||||..|||.|||.:||||.|||||||||||||.|.|||:
Mouse   332 YNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKI 396

  Fly   669 IGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAF 733
            :|.:|||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :||||||
Mouse   397 VGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNLKDAF 458

  Fly   734 AKSMDLIDVIVD-TGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRN 797
            |:||:||||.|: .|:..|..........:|:..:.....       ||:|..|.:
Mouse   459 ARSMELIDVAVEKAGESANTKDSVDDNHLSPSRWKWARKA-------LSETSSNKS--------- 507

  Fly   798 PATTGTGCYKN-YDHVA-NLRNSNLHNRRGSS-------------SEQDAVPPYSFDNPNARQTS 847
                    |:| |..|: |..:.:|:|...||             :|.....|:|..||:.::
Mouse   508 --------YENKYQEVSQNDSHEHLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQE-- 562

  Fly   848 MMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVAT 912
                   :.|:..:.:::.:.::.:...:|:              .||....:|...|.::..:.
Mouse   563 -------QPERPCVYEEEIEMEEVICPQEQL--------------AVAQTEVIVDMKSTSSIDSF 606

  Fly   913 ATNASNASNT------APGSEGAEGGGDGDGGGVDDD---------NLSQAKG----------LP 952
            .:.|::.:.|      .|.:...:.....|..|.|:.         .||:.||          .|
Mouse   607 TSCATDFTETERSPLPPPSASHLQMKFPTDLPGTDEHQRARAPPFLTLSRDKGPAAREAAVDYAP 671

  Fly   953 IQMMIT-----------PGEVAE-----------LRRQVALENLQNQRMD------NLEQDVPVE 989
            |.:.:.           |...::           |:.:....|.|..|..      :..:.:||
Mouse   672 IDITVNLDAGASHGPLQPDSASDSPKSSLKGSNPLKSRSLKVNFQENRASAPQTPPSTARPLPV- 735

  Fly   990 FECCFCTTKDFKEFTDAEGVISLPTSDFHKPICLEMRLAAAGRQAGAYGLLSPLPAPLPPL---- 1050
                  ||.||          .|.|......|.||                ..||...|||
Mouse   736 ------TTADF----------PLTTPQHMSTILLE----------------EALPQGQPPLLEAD 768

  Fly  1051 -----HGPLLALPPPPP 1062
                 .||.....|..|
Mouse   769 DSAHCQGPSKGFSPRFP 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	75/106 (71%)
		BTB_2	309..408	CDD:280393	69/98 (70%)
		Ion_trans	501..700	CDD:278921	154/198 (78%)
		Ion_trans_2	613..696	CDD:285168	64/82 (78%)
Kcnb2	NP_001091998.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		6/13 (46%)
		BTB	37..143	CDD:197585	74/105 (70%)
		BTB_2	37..136	CDD:280393	69/98 (70%)
		Ion_trans	230..428	CDD:278921	154/198 (78%)
		Ion_trans_2	341..422	CDD:285168	63/80 (79%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	381..386		4/4 (100%)
		Kv2channel	471..755	CDD:281514	55/363 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..534		10/47 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..742		11/78 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..859		7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I944
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	671	1.000	Inparanoid score	I737
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002877
OrthoInspector	1	1.000	-	-		otm44008
orthoMCL	1	0.900	-	-		OOG6_101602
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3999
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.990