DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and KCNB2

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_004761.2	Gene:	KCNB2 / 9312	HGNCID:	6232	Length:	911	Species:	Homo sapiens

Alignment Length:	1001	Identity:	418/1001 - (41%)
Similarity:	566/1001 - (56%)	Gaps:	195/1001 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 LQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEA 344
            |.|..|||..|: ||||..|.:||..:.||.|||||:.||||||||:|||.||||:||:|.|||:
Human     9 LNRKTSRSTLSL-PPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHES 72

  Fly   345 IVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCC 409
            ::|:||||:|.:|||||||||.:|:||||||||||||:::|||.|:|..:|:|||:||:||||||
Human    73 LLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCC 137

  Fly   410 QHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILF 474
            |.:|||:||.::||:|:|||::|:|:.|||....|.:.:|.||:||||||:|.||:::|::||||
Human   138 QARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILF 202

  Fly   475 IVLSTIALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLN 538
            ||||||||:|||||:||..|. |...||.|||.||||||.|||:||:|||.:||:|||||||.||
Human   203 IVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLN 267

  Fly   539 IIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNS 603
            :|||||||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.|
Human   268 VIDLLAILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRS 331

  Fly   604 YKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKV 668
            |.|||||:||||||::|||||.:||||||..|||.|||.:||||.|||||||||||||.|.|||:
Human   332 YNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKI 396

  Fly   669 IGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAF 733
            :|.:|||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :||||||
Human   397 VGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNLKDAF 458

  Fly   734 AKSMDLIDVIVD-TGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHN---------LSQTDGNST 788
            |:||:||||.|: .|:..|..........:|:..:......|....|         :||.|.:.
Human   459 ARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHE- 522

  Fly   789 EGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFDNPNARQTSMMAMES 853
            :..:||..:|           .|::..:...|:|      |.....|:|..||:.::
Human   523 QLNNTSSSSP-----------QHLSAQKLEMLYN------EITKTQPHSHPNPDCQE-------- 562

  Fly   854 YRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVATATNASN 918
             :.|:.:..:::.:.::.:...:|:              .||....:|...|.::..:..:.|::
Human   563 -KPERPSAYEEEIEMEEVVCPQEQL--------------AVAQTEVIVDMKSTSSIDSFTSCATD 612

  Fly   919 ASNT------APGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQVALENLQNQ 977
            .:.|      .|.:...:.....|..|.::.  .:|:|.|
Human   613 FTETERSPLPPPSASHLQMKFPTDLPGTEEH--QRARGPP------------------------- 650

  Fly   978 RMDNLEQDVPVEFECCFCTTKDFKEFTDAEGVISLPTSDFHKPICLEMRLAAAGRQAGAYGLLSP 1042
                            |.|....|.....:|.:.      :.|:.:.:.|.|:|.|.   ||.||
Human   651 ----------------FLTLSREKGPAARDGTLE------YAPVDITVNLDASGSQC---GLHSP 690

  Fly  1043 L------PAPLPPLHG--PLLALP----------PPPPLPPTSCAAVLLPAISQSSSTSSSYGTT 1089
            |      .:|...|.|  ||.:..          ..|..||::  |..||.      |::.:..|
Human   691 LQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPST--ARPLPV------TTADFSLT 747

  Fly  1090 TS---TTIAL---------PL---DVSLRYGATICSSSN--------------FNHNYNNNFNTT 1125
            |.   :||.|         ||   :||     ..|...:              |:.....:|...
Human   748 TPQHISTILLEETPSQGDRPLLGTEVS-----APCQGPSKGLSPRFPKQKLFPFSSRERRSFTEI 807

  Fly  1126 TVGGGGNGTLLFGG----NYNGSNNNNADL-----------ASVDSS---DTYASCQTHPFLSQG 1172
            ..|...:...|.|.    ..:.|.|..||.           .||.||   ||..:|:...:.:..
Human   808 DTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSPQDTGHNCRQDIYHAVS 872

  Fly  1173 DLTADFNDEACALD--IDMDNLYINP 1196
            ::..|.:.|.|.::  :....::.||
Human   873 EVKKDSSQEGCKMENHLFAPEIHSNP 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	75/106 (71%)
		BTB_2	309..408	CDD:280393	69/98 (70%)
		Ion_trans	501..700	CDD:278921	155/198 (78%)
		Ion_trans_2	613..696	CDD:285168	64/82 (78%)
KCNB2	NP_004761.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		6/13 (46%)
		BTB	37..143	CDD:197585	74/105 (70%)
		BTB_2	37..136	CDD:280393	69/98 (70%)
		Ion_trans	230..428	CDD:278921	155/198 (78%)
		Ion_trans_2	341..422	CDD:285168	63/80 (79%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	381..386		4/4 (100%)
		Kv2channel	471..759	CDD:281514	64/388 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..534		7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..571		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..665		7/70 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..739		15/58 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	760..865		21/109 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..911		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I956
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	668	1.000	Inparanoid score	I751
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002877
OrthoInspector	1	1.000	-	-		otm41959
orthoMCL	1	0.900	-	-		OOG6_101602
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3999
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.890