DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shab and KCNG4

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_758857.1	Gene:	KCNG4 / 93107	HGNCID:	19697	Length:	519	Species:	Homo sapiens

Alignment Length:	481	Identity:	173/481 - (35%)
Similarity:	274/481 - (56%)	Gaps:	50/481 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 VNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFS 369
            :...:.|||||.|:.:.|.||:|.|.:||.:||.|.::|.||:|||||.....|:||||.|.:|.
Human    57 LKKEILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFG 121

  Fly   370 SILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAES-LRQ 433
            .|::|...|||.::.|||.|:|.::|.|||::|.:||.||..|..::.|.:.|..:...|. |||
Human   122 VIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLHREDVLRQ 186

  Fly   434 RDEEEFGEGKCAEY---QKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDN 495
            :.|........:.:   ...|.|::|.|.:....:|.|.:||||:..:.::|.::|:|.|:
Human   187 QRETRRPASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLR---- 247

  Fly   496 GTPQDNPQ-------LAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLF 553
             ..:|..:       :.:||.:|:.||:||:.|||..:.||.:||:|.|||||:|||.||:|||.
Human   248 -AEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLA 311

  Fly   554 LLE------TNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLML 612
            :.|      ...:.:...:.|..|::|.|.:|||.:::|||||.|||:||.|:|...:|.|||:|
Human   312 VSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLL 376

  Fly   613 FLAMGVLIFSSLAYFAEKDE-KDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCIC 676
            |||:.:.:||.|.|.|||:. :..:|.|||.::|||.|:||||||||:.|.:..|:::.....:.
Human   377 FLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILS 441

  Fly   677 GVLVIALPIPIIVNNFAEFYKNQMRREKALKRR-------------EALDRAKREGSIVSFHHIN 728
            |:|::|.|...|.:.|:..|....:.::.|:.|             |.||     ..:.|.|.:
Human   442 GILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELLD-----PHVASEHEL- 500

  Fly   729 LKDAFAKSMDLIDVIVDTGKQTNVVH 754
                   ..|:.|:|:: |....::|
Human   501 -------MNDVNDLILE-GPALPIMH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	51/106 (48%)
		BTB_2	309..408	CDD:280393	48/98 (49%)
		Ion_trans	501..700	CDD:278921	88/212 (42%)
		Ion_trans_2	613..696	CDD:285168	34/83 (41%)
KCNG4	NP_758857.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		BTB	61..161	CDD:197585	48/99 (48%)
		BTB_2	61..160	CDD:280393	48/98 (49%)
		Ion_trans	262..465	CDD:278921	88/202 (44%)
		Ion_trans_2	377..459	CDD:285168	34/81 (42%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	418..423		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910