Protein Alignment Shab and KCNQ4

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_004691.2
• Gene: KCNQ4 / 9132
• HGNCID: 6298
• Length: 695
• Species: Homo sapiens
• Alignment Length: 705
• Identity: 147/705 - (20%)
• Similarity: 263/705 - (37%)
• Gaps: 201/705 - (28%)

  Fly   415 QRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKP-NTSFAARVIAVISILFIVLS 478
            ||....|:..|:                    .|.:::.:||:| ..:|...|.    |..:|.|
Human    71 QRSSAAHKRYRR--------------------LQNWVYNVLERPRGWAFVYHVF----IFLLVFS 111

  Fly   479 TIALT-LNTLPQLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILR-FSAS--------PDKWKFF 533
            .:.|: |:|:.:.|.:.|..      |.::|.|.|..|.||||:| :||.        ..:::|.
Human   112 CLVLSVLSTIQEHQELANEC------LLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFA 170

  Fly   534 KGGLNIIDLLAILPYFVSLFLLETNKN--ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSL 596
            :....:||.:..:. .|::....|..|  ||...:.:       |.::|||::::.|.....:.|
Human   171 RKPFCVIDFIVFVA-SVAVIAAGTQGNIFATSALRSM-------RFLQILRMVRMDRRGGTWKLL 227

  Fly   597 GFTLRNSYKELGLLMLFLAMGVLIFSS-LAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIY 660
            |..:....||| :...::...||||:| |.|.|||| .::.|.|..::.||..||:||:||||..
Human   228 GSVVYAHSKEL-ITAWYIGFLVLIFASFLVYLAEKD-ANSDFSSYADSLWWGTITLTTIGYGDKT 290

  Fly   661 PTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRR-------------EAL 712
            |.|.||:|:.....:.|:...|||..|:.:.||...:.|.|::...|||             .:.
Human   291 PHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYST 355

  Fly   713 DRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPG 777
            |.::...:...:::.::..:|.:...|.:.:                |...|.|.:.|:|:.||
Human   356 DMSRAYLTATWYYYDSILPSFRELALLFEHV----------------QRARNGGLRPLEVRRAP- 403

  Fly   778 HNLSQTDGNSTEGESTSGRNPATTGTGCYK-----------NYDHVANLRNSNLHNRRGSSSEQD 831
                ..||      :.|...|..|   |::           :...:.:........||...|:|.
Human   404 ----VPDG------APSRYPPVAT---CHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQH 455

  Fly   832 AVPPYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVAN 896
            ..||....:|::.|.......:..::..:...:.:.:....|:.:...:.||:..       ||.
Human   456 LAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEE-------VAE 513

  Fly   897 NLA----------MVAASSAATAV----------------------------------------A 911
            ..:          |.|..:...::                                        :
Human   514 EKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKS 578

  Fly   912 TATNASNASNTAPGSEGAEGGGD---GDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQVALEN 973
            ..|.........||...|...||   .|...||:          |.||   |.|.::.:||
Human   579 LQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDE----------ISMM---GRVVKVEKQV---- 626

  Fly   974 LQNQRMDNLEQDVPVEFECCFCTTKDFKEFTDAE-GVISLP------TSDFHKPI 1021
               |.::: :.|:.:.|     .::..:..|.|. |.:.:|      |||:|.|:
Human   627 ---QSIEH-KLDLLLGF-----YSRCLRSGTSASLGAVQVPLFDPDITSDYHSPV 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	74/248 (30%)
KCNQ4	NP_004691.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Ion_trans	98..330	CDD:459842	75/251 (30%)
		Interaction with CALM. /evidence=ECO:0000269|PubMed:29429937	342..351		0/8 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..480		16/93 (17%)
		KCNQ_channel	464..647	CDD:460954	28/215 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..515		5/25 (20%)
		Interaction with CALM. /evidence=ECO:0000250|UniProtKB:P51787	535..549		0/13 (0%)
		C-terminal assembly domain (tetramerization). /evidence=ECO:0000269|PubMed:17329207	546..650		20/129 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..606		5/18 (28%)