Protein Alignment Shab and KCNK5

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_003731.1
• Gene: KCNK5 / 8645
• HGNCID: 6280
• Length: 499
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 112/627 - (17%)
• Similarity: 200/627 - (31%)
• Gaps: 237/627 - (37%)

  Fly   373 NFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEE 437
            |:| |.|||::.|...|...      |:|::.                  |:..:|.
Human    37 NYY-TQKLHLLKEFPCLGQE------GLDKIL------------------EVVSDAA-------- 68

  Fly   438 EFGEGKC----AEYQKYLWELLEKPNTS-FAARVIAVISI-----------LFIVLSTIALTLNT 486
              |:|..    ..:..:.|     ||.. |||.||..|..           ||.|...:.
Human    69 --GQGVAITGNQTFNNWNW-----PNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLF----- 121

  Fly   487 LPQLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVS 551
                     |.|           :|:||.:.           ..|||.|
Human   122 ---------GVP-----------LCLTWISA-----------LGKFFGG---------------- 139

  Fly   552 LFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAM 616
                                          |..:|.:.   |...|.:||.:  ::...::|:..
Human   140 ------------------------------RAKRLGQF---LTKRGVSLRKA--QITCTVIFIVW 169

  Fly   617 GVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGD----IYPTT---ALGKVIGTVCC 674
            |||:...:..|.....:...::   |..:::.||::|:|:||    :.|:.   ||.:....:..
Human   170 GVLVHLVIPPFVFMVTEGWNYI---EGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWI 231

  Fly   675 ICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHH----INLKDAFAK 735
            ..|:..::|.:...|:.|.|.:       ||:|:|    |.:|:.|..|..|    :.:|.:.|
Human   232 YLGLAWLSLFVNWKVSMFVEVH-------KAIKKR----RRRRKESFESSPHSRKALQVKGSTA- 284

  Fly   736 SMDLIDVIVDTGKQTNVVHPKGKRQSTPN-----IGRQTLDV----QSAPGHNLSQTDGNSTEGE 791
                       .|..|:.....|::.|.|     ||::.:..    ::.||      .|...:|.
Human   285 -----------SKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPG------PGLGPQGG 332

  Fly   792 STSGRNPATTGTGCY-KN----YDHVANLRNSNLHNRRGSSSEQDAVPPYSFDNPNARQTSMMAM 851
            ......|:......| ||    .:.|:....|..|..|  |.:::||.....|:..|.:..|..:
Human   333 GLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSR--SPDEEAVARAPEDSSPAPEVFMNQL 395

  Fly   852 ESYRRE--------------QQALLQ--------QQQQQQQQMLQMQQIQQKAPNGNGGATGGGV 894
            :....|              |.|.:.        ..::..:..|:.....:::|.....|.   .
Human   396 DRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAK---A 457

  Fly   895 ANNLAMVAASSAATAVATAT----------NASNASNTAPGS 926
            ..|:....:||.:|..:|.:          |..|.:|:..|:
Human   458 PLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	10/40 (25%)
		Ion_trans	464..700	CDD:459842	42/253 (17%)
KCNK5	NP_003731.1	Ion_trans_2	<83..137	CDD:462301	18/94 (19%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	98..103		1/4 (25%)
		Ion_trans_2	171..243	CDD:462301	15/74 (20%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	203..208		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..335		4/28 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..388		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..499		11/73 (15%)