DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcnq1

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_114462.2	Gene:	Kcnq1 / 84020	RGDID:	621503	Length:	669	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	141/633 - (22%)
Similarity:	228/633 - (36%)	Gaps:	202/633 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 QKYLWELLEKPN------TSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQLAM 506
            |..::..||:|.      ..|...:|.::.::|.|||||       .|...:..||      |..
  Rat   107 QGRVYNFLERPTGWKCFVYHFTVFLIVLVCLIFSVLSTI-------EQYAALATGT------LFW 158

  Fly   507 VEAVCITWFTLEYILRFSASPDK------W---KFFKGGLNIIDLLAILPYFVSLFLLETNKNAT 562
            :|.|.:.:|..||::|..::..:      |   :|.:..::||||:.::...|.|.:  .:|...
  Rat   159 MEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCV--GSKGQV 221

  Fly   563 DQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS-LAY 626
            .....:|.:    |.::|||:|.:.|.....:.||..:....:|| :..|::....||||| ..|
  Rat   222 FATSAIRGI----RFLQILRMLHVDRQGGTWRLLGSVVFIHRQEL-ITTLYIGFLGLIFSSYFVY 281

  Fly   627 FAEKDEKD----TKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPI 687
            .||||..:    .:|.|..:..||..:|:||:||||..|.|.:||.|.:...:..:...|||..|
  Rat   282 LAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGI 346

  Fly   688 IVNNFAEFYKNQMRREKALKRR-----EALDRAKR----EGSIVSFHHINLKDAFAKSMDLI--- 740
            :.:.|| ....|.:|:|...|:     ..:..|.|    |....|...|.::.. |:|..|:
  Rat   347 LGSGFA-LKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVRKP-ARSHTLLSPS 409

  Fly   741 -----DVIV---------DTG-----KQTNVVH-----PKGKRQSTPNIGRQTLDVQSAP----- 776
                 .|:|         |.|     |..||.|     |:.:|....:|......|:.:|
  Rat   410 PKPKKSVMVKKKKFKLDKDNGLSPGEKIFNVPHITCDPPEDRRPDHFSIDGYDSSVRKSPTLLEV 474

  Fly   777 --GHNL---SQTDGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNR------------- 823
              .|.|   |..:....|||:.  ..|.|          ||:.||:   |:|
  Rat   475 STPHFLRTNSFAEDLDLEGETL--LTPIT----------HVSQLRD---HHRATIKVIRRMQYFV 524

  Fly   824 --------RGSSSEQDAVPPYSFDNPNARQTSMMAMESYRREQQAL------------------- 861
                    |.....:|.:..||..:.|   ..:...|..||..|::
  Rat   525 AKKKFQQARKPYDVRDVIEQYSQGHLN---LMVRIKELQRRLDQSIGKPSLFIPISEKSKDRGSN 586

  Fly   862 --------LQQQQQQQQQML--------QMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAV 910
                    ::.:..|..|.|        |:..:||          ||...||.:.|.||.
  Rat   587 TIGARLNRVEDKVTQLDQRLVIITDMLHQLLSLQQ----------GGPTCNNRSQVVASD----- 636

  Fly   911 ATATNASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMIT 958
                                     :||.::.:....:..||....:|
  Rat   637 -------------------------EGGSINPELFLPSNSLPTYEQLT 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585
		BTB_2	309..408	CDD:280393
		Ion_trans	501..700	CDD:278921	60/212 (28%)
		Ion_trans_2	613..696	CDD:285168	32/87 (37%)
Kcnq1	NP_114462.2	Ion_trans	123..359	CDD:395416	72/256 (28%)
		Selectivity filter. /evidence=ECO:0000250	312..317		3/4 (75%)
		Interaction with CALM. /evidence=ECO:0000250\|UniProtKB:P51787	370..382		2/11 (18%)
		KCNQ_channel	<511..617	CDD:397540	14/108 (13%)
		Interaction with CALM, calcium-dependent. /evidence=ECO:0000250\|UniProtKB:P51787	515..529		0/13 (0%)
		Interaction with KCNE1 C-terminus. /evidence=ECO:0000250\|UniProtKB:P51787	535..572		8/39 (21%)
		Interaction with AKAP9. /evidence=ECO:0000250\|UniProtKB:P51787	588..616		3/27 (11%)
		C-terminal assembly domain. /evidence=ECO:0000250\|UniProtKB:P51787	589..620		4/30 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810