DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcns3

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001376159.1	Gene:	Kcns3 / 83588	RGDID:	621527	Length:	491	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	196/464 - (42%)
Similarity:	297/464 - (64%)	Gaps:	32/464 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 VSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILN 373
            |::||||.:..|...||.|.||||||:|..|.:.|||:|||||||:||.||:|||:|..|..:||
  Rat    17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLN 81

  Fly   374 FYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHE------------EMRK 426
            ||.|||||:::|:||.:|..::||||::||:::|||..:|.:|||..||            :...
  Rat    82 FYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSSRYQERKEESHEKDWDQKSNDVSTDSSF 146

  Fly   427 EAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQ 491
            |..||.:::.|:|.|.:..:.:|.:|..:|.|....:|::||:.|:..::.|.:|:.::::.:.|
  Rat   147 EESSLFEKELEKFDELRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQ 211

  Fly   492 HIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLE 556
            :.|...  |:|.|..||..||.|||.|..:|..|:|.:.||:|..|||||.::|:|::.:| .::
  Rat   212 NEDGEV--DDPVLEGVEIACIAWFTGELAIRLVAAPSQKKFWKNPLNIIDFVSIIPFYATL-AVD 273

  Fly   557 TNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIF 621
            |.:..::..:::.:|||:.|:|||.|||||||||.||:|||.|||:||.|:|||:|||::|:.||
  Rat   274 TKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIF 338

  Fly   622 SSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIP 686
            |.|.|..||||..:...|||..:|||.|:||||||||.:|.|..||:|.:.|.|||:||:||||.
  Rat   339 SVLIYSVEKDELASSLTSIPICWWWATISMTTVGYGDTHPVTLAGKIIASTCIICGILVVALPIT 403

  Fly   687 IIVNNFAEFYKNQMRREKALKRREALDRAKRE--GSIVSFHHINLKD-------AFAKSMDLIDV 742
            ||.|.|:::|:.|...:        :|:...:  .......:.|::|       ||..|:..|.:
  Rat   404 IIFNKFSKYYQKQKDMD--------VDQCSEDPPEKCHELPYFNIRDVYAQQVHAFITSLSSIGI 460

  Fly   743 IVDTGKQTN 751
            :|.....|:
  Rat   461 VVSDPDSTD 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	59/106 (56%)
		BTB_2	309..408	CDD:280393	55/98 (56%)
		Ion_trans	501..700	CDD:278921	103/198 (52%)
		Ion_trans_2	613..696	CDD:285168	46/82 (56%)
Kcns3	NP_001376159.1	BTB_POZ_KCNS3	15..122	CDD:349735	58/104 (56%)
		Ion_trans	184..417	CDD:395416	112/235 (48%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920