Protein Alignment Shab and kcnq1.2

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_073798625.1
• Gene: kcnq1.2 / 796289
• ZFINID: ZDB-GENE-130530-935
• Length: 704
• Species: Danio rerio
• Alignment Length: 587
• Identity: 130/587 - (22%)
• Similarity: 220/587 - (37%)
• Gaps: 168/587 - (28%)

  Fly   414 HQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKY---------LWELLEKPN------TSFA 463
            |.::...|.: |::..|:.....|.........:..|         ::..||:|.      ..|.
Zfish    75 HTKEPPAHSQ-RRQPVSIHSGPGETLAAAARFTHSPYHAKTSMQGDVYNFLERPAGLRCFLYHFL 138

  Fly   464 ARVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILR-FSAS- 526
            ..::.::.::|.|||||.         |:.|..|    ..|..:|.|.:.:|..||::| :||.
Zfish   139 VFLMVLVCLIFSVLSTIE---------QYADFAT----GSLFWMEIVLVVFFGTEYVVRLWSAGC 190

  Fly   527 -------PDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKN----ATDQFQDVRRVVQVFRIMRI 580
                   ..:.:|.:..::||||:.::   .|:.:|....|    ||...:.:       |.::|
Zfish   191 RSKYVGIKGRLRFIRKPISIIDLIVVV---ASVVVLSVGSNGQVFATSAIRGI-------RFLQI 245

  Fly   581 LRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS-LAYFAEKDEKD----TKFVSI 640
            ||:|.:.|.....:.||..:....:|| :..|::....||||| ..|.||||..|    |.|.|.
Zfish   246 LRMLHVDRQGGTWRLLGSVVFIHRQEL-ITTLYIGFLGLIFSSYFVYLAEKDAVDEEGKTGFSSY 309

  Fly   641 PETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALP--------------------- 684
            .:..||..:|:||:||||..|.|.:||.|.:...:..:...|||
Zfish   310 ADALWWGVVTVTTIGYGDKVPQTWIGKAIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHF 374

  Fly   685 ---------------------------------------IPII------VNNFAEFYKNQMRREK 704
                                                   ||||      ..||....|...|:.|
Zfish   375 NRQIPAAASLIQTLWRCYACEKSDSCTATWKMYVLTGDYIPIINSENSSPGNFRRLSKRYKRKPK 439

  Fly   705 ALKRREALDRA-KREGSI--VSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIG 766
            :|:...:|..| :|..||  :::.||..|||           |.|...|.:.  |..|.|    .
Zfish   440 SLRDNGSLGPAGERALSIPQITYDHIEDKDA-----------VFTDDSTGIA--KLFRSS----D 487

  Fly   767 RQ------TLDVQSAP------GHNLSQTDGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSN 819
            ||      ||...|:|      |.::|:.:....|.:.|:...|....|       ..::|..|.
Zfish   488 RQRSWSAFTLSCPSSPVKKKLDGPDISRNNSLVDELDFTTEDIPLPVVT-------DASHLLRSP 545

  Fly   820 LHNRRGSSSEQDAVPPYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPN 884
            |     .:.|:::|.....:..........|::..||.|..:.:::.||.::...::.:.::...
Zfish   546 L-----VAKEEESVSTQHLNTSRLSHAHRSAIKVIRRMQYFVARRKFQQARKPYDVRDVIEQYSQ 605

  Fly   885 GN 886
            |:
Zfish   606 GH 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	130/587 (22%)
		Ion_trans	464..700	CDD:459842	77/319 (24%)
kcnq1.2	XP_073798625.1	None