DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcnv1

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_080476.2	Gene:	Kcnv1 / 67498	MGIID:	1914748	Length:	503	Species:	Mus musculus

Alignment Length:	514	Identity:	204/514 - (39%)
Similarity:	319/514 - (62%)	Gaps:	48/514 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 SQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLG-- 334
            |.|..:|:|....|....|....||.      |:....::||||.|..:..:.|...||||||
Mouse    13 SSSLDSGSLTSLDSSVFCSEGEGEPL------ALGDCFTVNVGGSRFVLSQQALSCFPHTRLGKL 71

  Fly   335 --------RLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAF 391
                    ||.......:.:|||||.:..||||||||..::|..:|::||||:||:::::|.|:|
Mouse    72 AVVVASYRRLGALAAAPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSF 136

  Fly   392 SDDLEYWGVDELYLESCCQHKYHQRKENVHE--EMRKEA--ESLRQRDEEEFGEGKCAEYQKYLW 452
            ..:::|||:|||.::|||:.:|.:||| :.|  :.:|:.  :..:...|::|.:|.|...::.||
Mouse   137 LQEIQYWGIDELSIDSCCRDRYFRRKE-LSETLDFKKDTDDQESQHESEQDFSKGPCPTVRQKLW 200

  Fly   453 ELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQ-LAMVEAVCITWFT 516
            ::||||.:|.|||:..||||:|:.:|.:.:.|.: .:|..:       |.| |.::|.|||:|||
Mouse   201 DILEKPGSSTAARIFGVISIIFVAVSIVNMALMS-AELSWL-------NLQLLEILEYVCISWFT 257

  Fly   517 LEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLE--TNKNATDQFQDVRRVVQVFRIMR 579
            .|::|||....|:..|.:...||||||||||::::| |:|  :..:.|.:.::|.|:|||.|::|
Mouse   258 GEFVLRFLCVKDRCHFLRKVPNIIDLLAILPFYITL-LVESLSGSHTTQELENVGRLVQVLRLLR 321

  Fly   580 ILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETF 644
            .||:|||.||||||:|||.|:...|:|:|||:|||::|:.|||::.||||:...||.|.|:|..:
Mouse   322 ALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTIEYFAEQSIPDTTFTSVPCAW 386

  Fly   645 WWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRR 709
            |||..:|||||||||.|.|..||::..:|.:.|:||:||||.||.:.|:..|.....:|.|:::|
Mouse   387 WWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQR 451

  Fly   710 EALDRAKREGSIVSFHHINLKDAFAKS-MDLIDVIVDTGKQTNVVHPKGK-RQSTPNIG 766
            |||.:..:..:..|:..:||:|.:|:| |:::.:             ||: |.||.:.|
Mouse   452 EALKKLTKNIATDSYISVNLRDVYARSIMEMLRL-------------KGRERASTRSSG 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	48/116 (41%)
		BTB_2	309..408	CDD:280393	44/108 (41%)
		Ion_trans	501..700	CDD:278921	101/201 (50%)
		Ion_trans_2	613..696	CDD:285168	42/82 (51%)
Kcnv1	NP_080476.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		2/6 (33%)
		BTB_POZ	44..163	CDD:365784	49/118 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..192		4/20 (20%)
		Ion_trans	212..438	CDD:366146	110/234 (47%)
		Selectivity filter. /evidence=ECO:0000250	395..400		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920