Protein Alignment Shab and Kcng4

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_080010.2
• Gene: Kcng4 / 66733
• MGIID: 1913983
• Length: 506
• Species: Mus musculus
• Alignment Length: 458
• Identity: 171/458 - (37%)
• Similarity: 268/458 - (58%)
• Gaps: 33/458 - (7%)

  Fly   284 HSRSMSSI----PPPEPFMI---------------AQSKAVNSRVSINVGGVRHEVLWRTLERLP 329
            |..|.|.:    |.|||..:               |..:|....:.:||||.|:.:.|.||:..|
Mouse    16 HFGSCSPLSQLWPGPEPKSVKGLYYSRARKVGNQDASPEANLKEILVNVGGQRYLLPWSTLDAFP 80

  Fly   330 HTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDD 394
            .:||.|||.|.:||.|.:|||||.....|:||||:|.:|..|::|...|||.::.|||.|:|.::
Mouse    81 LSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCALSFREE 145

  Fly   395 LEYWGVDELYLESCCQHKYHQRKENVHEEMRKEA---ESLRQRDEEEFGEGKCAEYQKYLWELLE 456
            |.|||::|..||.||..|..::.|...|..|:||   :..||....|....:.|.....|.|::|
Mouse   146 LSYWGIEETNLERCCLRKLLKKLEEAAELRREEAAQRQQQRQACHSEVQASRWARSMNQLREMVE 210

  Fly   457 KPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQ---LAMVEAVCITWFTLE 518
            .|.:....:|.|.:|:||:..:.::|.::|:|..: .:.|..:...:   :.:||::|:.||:||
Mouse   211 DPQSGLPGKVFACLSVLFVATTAVSLCVSTMPDFR-AEEGKGECTRKCYYIFVVESICVAWFSLE 274

  Fly   519 YILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQ------FQDVRRVVQVFRI 577
            :.|||..:|:|.:||:|.||:||:|||.||:|||.:.:.:..|.::      .:.|..|::|.|.
Mouse   275 FCLRFVQAPNKCQFFRGPLNVIDILAISPYYVSLAVSDESPEAGERPSSSSYLEKVGLVLRVLRA 339

  Fly   578 MRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDE-KDTKFVSIP 641
            :|||.:::|||||.|||:||.|:|...:|.||||||||:.|.:||.|.|.||.:. :..:|.|||
Mouse   340 LRILYVMRLARHSLGLQTLGLTVRRCAREFGLLMLFLAVAVTLFSPLVYVAENESGRVLEFTSIP 404

  Fly   642 ETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKAL 706
            .::|||.|:||||||||:.|.:..|:::.....:.|:|::|.|...|.:.|:..|....|.::.:
Mouse   405 ASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKREQEQV 469

  Fly   707 KRR 709
            :.|
Mouse   470 QAR 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	50/107 (47%)
		Ion_trans	464..700	CDD:459842	97/245 (40%)
Kcng4	NP_080010.2	BTB_POZ	58..167	CDD:453885	50/108 (46%)
		Ion_trans	219..463	CDD:459842	97/244 (40%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	416..421		4/4 (100%)