Protein Alignment Shab and Kcns2

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_076456.1
• Gene: Kcns2 / 66022
• RGDID: 621525
• Length: 477
• Species: Rattus norvegicus
• Alignment Length: 452
• Identity: 192/452 - (42%)
• Similarity: 284/452 - (62%)
• Gaps: 27/452 - (5%)

  Fly   299 IAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDR 363
            ::::...:..:.|||||.:..:...||.|.|.||||||..|.:.|||:||||||.....|::|||
  Rat     9 LSETDVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDR 73

  Fly   364 HPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEA 428
            :|:.|..:|:||.|||||::.|:||.:||.::||||::|.:::|||.:.||.||  |..|..|..
  Rat    74 NPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRK--VEPEQEKWD 136

  Fly   429 ESLRQ--------------RDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLST 479
            |...|              .|..:|.......:::.||..|:.|..|..:||.:|:|||.::.|.
  Rat   137 EQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSI 201

  Fly   480 IALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLL 543
            |.:.||:||..|..|: |.|.::|:..:||...|.|||.|.:.||:.:||..||||..||:|||:
  Rat   202 ITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLM 266

  Fly   544 AILPYFVSLFL-LETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKEL 607
            :|:|::::|.: |....:.|  ..::.||.||.|:|||.||||||||||||:|||.||:.||||:
  Rat   267 SIVPFYITLVVNLVVESSPT--LANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEV 329

  Fly   608 GLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTV 672
            |||:|:|::|:.|||.:||..||:|.: ...:||..:|||.::||||||||:.|.|..||:..:.
  Rat   330 GLLLLYLSVGISIFSVVAYTIEKEENE-GLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASA 393

  Fly   673 CCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFA 734
            |.:.|:||:.|||.:|.|.|:.||:.|.:.|.|::..:..|..|...|      :||:|.:|
  Rat   394 CILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPS------VNLRDYYA 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	52/107 (49%)
		Ion_trans	464..700	CDD:459842	114/237 (48%)
Kcns2	NP_076456.1	BTB_POZ_KCNS2	18..124	CDD:349734	52/105 (50%)
		Ion_trans	186..421	CDD:459842	114/237 (48%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)