Protein Alignment Shab and Kcnd3

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001257891.1
• Gene: Kcnd3 / 65195
• RGDID: 68394
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 681
• Identity: 201/681 - (29%)
• Similarity: 315/681 - (46%)
• Gaps: 115/681 - (16%)

  Fly   294 PEPFMIA-QSKAVNSRVSINVGGVRHEVLWR-TLERLPHTRLGRLRECTTHEAIVELCDDYSLAD 356
            |.|...| ::|..:..:.:||.|.|.:. || ||||.|.|.||     :|.:...     ::...
  Rat    26 PMPLAPADKNKRQDELIVLNVSGRRFQT-WRTTLERYPDTLLG-----STEKEFF-----FNEDT 79

  Fly   357 NEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVH 421
            .||||||.|:.|..:||||||||||.....|:.|:.|:|.::|:....:..||..:|..||
  Rat    80 KEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRK---- 140

  Fly   422 EEMRKEAESLRQRDEEEFGEGK--CAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTL 484
               |:.||.|...:|.|..:..  ...:::.:|...|.|:||..|.|...::..||.:|.|...:
  Rat   141 ---RENAERLMDDNESENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVV 202

  Fly   485 NTLPQLQHIDNGTPQDNPQLA----------MVEAVCITWFTLEYILRFSASPDKWKFFKGGLNI 539
            .|:|      .||...:.:|.          .::..|:..||:||:||..|:|.:::|.:..::|
  Rat   203 ETVP------CGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSI 261

  Fly   540 IDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSY 604
            ||::||:||::.|.:  ||.      :||.......|:.|:.||.|.:|||.||:.||:||::..
  Rat   262 IDVVAIMPYYIGLVM--TNN------EDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCA 318

  Fly   605 KELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVI 669
            .|||.|:..|.|.::||:::.::|||....:||.|||.:||:..:||||:||||:.|.|..||:.
  Rat   319 SELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIF 383

  Fly   670 GTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK---ALKRREALDRAKREGSIVSFHHINLKD 731
            |::|.:.||||||||:|:||:||:..|....|.:|   ..|.|.|..|..:.||..::.|.....
  Rat   384 GSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNG 448

  Fly   732 AFAKSMDLIDVIVD--TGKQTNVVHPK-----------------------GKRQSTPNIGRQTLD 771
            ...::::|.....:  .||.|:::..:                       ..|.||.. ..:.:|
  Rat   449 LLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIK-NHEFID 512

  Fly   772 VQSAPGHNLSQTDGN--STEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVP 834
            .|....:.:..:..|  ||...|.|..:..|| |.|.:......:|.||||
  Rat   513 EQMFEQNCMESSMQNYPSTRSPSLSSHSGLTT-TCCSRRSKKTTHLPNSNL-------------- 562

  Fly   835 PYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLA 899
                  |..|..||       :|...:..|..:|.........:..||.:        |:..|..
  Rat   563 ------PATRLRSM-------QELSTIHIQGSEQPSLTTSRSSLNLKADD--------GLRPNCK 606

  Fly   900 MVAASSAATAVAT--ATNASNASNTAPGSEG 928
            ....::|..::.|  |......|...|.|.|
  Rat   607 TSQITTAIISIPTPPALTPEGESRPPPASPG 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	40/108 (37%)
		Ion_trans	464..700	CDD:459842	93/245 (38%)
Kcnd3	NP_001257891.1	BTB_POZ_KCND3	6..143	CDD:349726	48/134 (36%)
		Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q9UK17	6..21
		Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q9UK17	70..78		0/12 (0%)
		Ion_trans	186..412	CDD:459842	91/239 (38%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	367..372		3/4 (75%)
		DUF3399	468..563	CDD:463381	20/116 (17%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000250|UniProtKB:Q9UK17	470..487		0/16 (0%)
		Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	474..489		0/14 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..565		15/62 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..647		6/22 (27%)