DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcna6

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_076444.1	Gene:	Kcna6 / 64358	RGDID:	62083	Length:	530	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	164/475 - (34%)
Similarity:	240/475 - (50%)	Gaps:	116/475 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 NSRVSINVGGVRHEVLWRTLERLPHTRLG----RLRECTTHEAIVELCDDYSLADNEYFFDRHPK 366
            :.|:.||:.|:|:|...|||...|.|.||    |:|             .:....|||||||:..
  Rat    40 SERLVINISGLRYETQLRTLSLFPDTLLGDPGRRVR-------------FFDPLRNEYFFDRNRP 91

  Fly   367 SFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAES 430
            ||.:||.:|:: |:|.....:.:..|.:::.::                        ::..||.:
  Rat    92 SFDAILYYYQSGGRLRRPVNVPLDIFMEEIRFY------------------------QLGDEALA 132

  Fly   431 LRQRDEEEFGEGKCAE-------YQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP 488
            ..:.||....||...|       :|:.:|.|.|.|.:|..||.||::|:|.|::|.:...|.|||
  Rat   133 AFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLP 197

  Fly   489 QLQ----------------------HIDNGTPQDN-----------------------------P 502
            |.:                      |.:....:|:                             .
  Rat   198 QFRADGRGGSNEGSGTRMSPASRGSHEEEDEDEDSYAFPGSIPSGGLGTGGTSSFSTLGGSFFTD 262

  Fly   503 QLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQD 567
            ...:||.:||.|||.|.::||||.|.|..||:..:|||||:||.|||::   |.|......:.|.
  Rat   263 PFFLVETLCIVWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFIT---LGTELVQRHEQQP 324

  Fly   568 VR-------------RVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVL 619
            |.             .:::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||.:||:
  Rat   325 VSGGSGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVI 389

  Fly   620 IFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALP 684
            :|||..||||.|:.|:.|.|||:.||||.:|||||||||:||.|..||::|::|.|.|||.||||
  Rat   390 LFSSAVYFAEADDVDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALP 454

  Fly   685 IPIIVNNFAEFYKNQMRREK 704
            :|:||:||..||..:..:|:
  Rat   455 VPVIVSNFNYFYHRETEQEE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	29/111 (26%)
		BTB_2	309..408	CDD:280393	29/103 (28%)
		Ion_trans	501..700	CDD:278921	105/240 (44%)
		Ion_trans_2	613..696	CDD:285168	50/82 (61%)
Kcna6	NP_076444.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		BTB_2	43..132	CDD:280393	31/125 (25%)
		BTB	43..126	CDD:197585	29/119 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..239		2/35 (6%)
		Ion_trans	260..469	CDD:278921	105/211 (50%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	361..374		7/12 (58%)
		Ion_trans_2	383..460	CDD:285168	47/76 (62%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	423..428		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000255	527..529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910