Protein Alignment Shab and kcnd2

DIOPT Version :9

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001076336.1
• Gene: kcnd2 / 570188
• ZFINID: ZDB-GENE-041210-70
• Length: 630
• Species: Danio rerio
• Alignment Length: 577
• Identity: 191/577 - (33%)
• Similarity: 292/577 - (50%)
• Gaps: 79/577 - (13%)

  Fly   292 PPPEPFMIAQSKAVNSRVSINVGGVRHEVLWR-TLERLPHTRLGRL-RECTTHEAIVELCDDYSL 354
            |||..    :.:..:..:.:||.|.|.:. || ||||.|.|.||.. |:...||
Zfish    29 PPPRD----KKRGQDGLIILNVSGTRFQT-WRNTLERYPDTLLGSTERDFFFHE----------- 77

  Fly   355 ADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKEN 419
            ..|||||||.|..|..|||||||||||.....|:.|:.::|.::|:....:..||..:|..|:
Zfish    78 ETNEYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGIIPEIIGDCCYEEYKDRR-- 140

  Fly   420 VHEEMRKEAESLRQRDEEEFGEGKCA----EYQKYLWELLEKPNTSFAARVIAVISILFIVLSTI 480
                 |:.||.: |.|||........    .:::.:|...|.|:||..|.|...::..||.:|.:
Zfish   141 -----RENAERI-QDDEENDNNNDLVMPDLSFRESMWRAFENPHTSTMALVFYYVTGFFIAVSVM 199

  Fly   481 ALTLNTLP---QLQHIDNGTPQDNPQLAM--VEAVCITWFTLEYILRFSASPDKWKFFKGGLNII 540
            |..:.|:|   .|......:..:...||.  ::..|:..||:||:||..|:|.::||.|..::||
Zfish   200 ANVVETVPCGISLNRAKELSCGERYALAFFCLDTACVMIFTVEYLLRLIAAPSRYKFVKSVMSII 264

  Fly   541 DLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYK 605
            |::||:||::.|.:       ||. :||.......|:.|:.||.|.:|||.||:.||:||::...
Zfish   265 DVVAIMPYYIGLVM-------TDN-EDVSGAFVTLRVFRVFRIFKFSRHSAGLRILGYTLKSCAS 321

  Fly   606 ELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIG 670
            |||.|:..|.|.::||:::.::|||....:||.|||..||:..:||||:||||:.|.|.:||:.|
Zfish   322 ELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIMGKIFG 386

  Fly   671 TVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK---ALKRREALDRA------------KREGS 720
            ::|.:.||||||||:|:||:||:..|....|.||   ..|.|.|..||            ||.|.
Zfish   387 SICSLSGVLVIALPVPVIVSNFSRIYHQSQRAEKRRAQKKTRLARIRAAKSGGANAYLQYKRNGM 451

  Fly   721 IVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQ------SAPGHN 779
            :|.......|:|....:...:...:| :..:::|...|..:...:..||.:..      :.|..:
Zfish   452 LVDMEEEASKEAGQALVCKANPTFET-QHHHLLHCLEKTTNHEFVDEQTYETSCMEVSLAKPSMS 515

  Fly   780 LSQTDGNSTEGEST--SGRNPATTGTGCYKNYDHVANLRNSNL-HNRRGSSSEQDAV 833
            .|.:..:|..|.|:  :.||..       |::    |:.|||: ..||||..|...:
Zfish   516 RSSSMSSSPHGLSSCCTRRNKR-------KSF----NVPNSNMAGGRRGSIQELSTI 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	44/108 (41%)
		BTB_2	309..408	CDD:280393	41/100 (41%)
		Ion_trans	501..700	CDD:278921	86/200 (43%)
		Ion_trans_2	613..696	CDD:285168	41/82 (50%)
kcnd2	NP_001076336.1	Shal-type	3..28	CDD:288455
		BTB	42..139	CDD:197585	44/108 (41%)
		BTB_2	42..131	CDD:280393	41/100 (41%)
		Ion_trans	228..416	CDD:278921	84/195 (43%)
		Ion_trans_2	330..410	CDD:285168	41/79 (52%)
		DUF3399	444..548	CDD:288712	23/115 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810