Protein Alignment Shab and kcnq5b

DIOPT Version :9

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_697081.4
• Gene: kcnq5b / 568646
• ZFINID: ZDB-GENE-090312-178
• Length: 974
• Species: Danio rerio
• Alignment Length: 1084
• Identity: 220/1084 - (20%)
• Similarity: 379/1084 - (34%)
• Gaps: 330/1084 - (30%)

  Fly   448 QKYLWELLEKPNTSFAARVIAVISILF---IVLSTIALTLNTLPQLQHIDNGTPQDNPQLAMVEA 509
            |.||:.:||:|. |:|....|.:.:|.   :|||    ..:|:|..|.:      .:..|.::|.
Zfish    97 QNYLYNVLERPR-SWAFIYHAFVFVLVFGCLVLS----VFSTIPDHQEM------ASQSLLILEF 150

  Fly   510 VCITWFTLEYILR-FSAS--------PDKWKFFKGGLNIIDLLAILPYFVSLFLL----ETNKNA 561
            |.|..|.||||:| :||.        ..:.:|.:....:||::.::   .|:.::    ::|..|
Zfish   151 VMIVVFGLEYIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDIIVLI---ASVAVVSAGSQSNIFA 212

  Fly   562 TDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS-LA 625
            |...:.:       |.::|||::::.|.....:.||..:....||| :...::...|||||| |.
Zfish   213 TSALRSL-------RFLQILRMVRMDRRGGTWKLLGSVVYAHSKEL-VTAWYIGFLVLIFSSFLV 269

  Fly   626 YFAEKD-EKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIV 689
            |..||: .||  |.:..:..||..||:||:||||..|.|..|:::.....:.|:....||..|:.
Zfish   270 YLVEKEFNKD--FATYADALWWGTITLTTIGYGDKTPKTWTGRMLSAGFALLGISFFTLPAGILG 332

  Fly   690 NNFAEFYKNQMRREKALKRRE-------------ALDR---------------------AKREGS 720
            :.||...:.|.|::...|||.             |.|.                     .|.:|.
Zfish   333 SGFALKVQEQHRQKHFEKRRNPAACLIQCVWRSYAADENSVSVATWKPHLKALHTCSPTKKDQGE 397

  Fly   721 IVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDG 785
            ..:...::.||                 :..:..|:|               ||......|.||.
Zfish   398 SATSQKLSFKD-----------------RVRMASPRG---------------QSIKSRQTSVTDR 430

  Fly   786 NSTEGE-STSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDA--VPPYSFDN------- 840
            .|...| ||.|.:||........| |......:..|.::..|:.|.:|  ....:||.
Zfish   431 RSPGAEISTDGSSPAKVQKSWSFN-DRTRFRPSLRLKSQSRSTPEGEANVTVDEAFDEKGCHCDM 494

  Fly   841 -----PNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAM 900
                 |:|.:|.:.|:...:      ....:::.::.|:...::......:.|        :|.|
Zfish   495 SVEDLPSALKTVIRAVRIMK------FHVAKKKFKETLRPYDVKDVIEQYSAG--------HLDM 545

  Fly   901 VAASSAATAVATATNASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAEL 965
            :.   ...::.|..:........|..:........||..::|          :.|:   |.|.::
Zfish   546 LC---RIKSLQTRVDQILGRGQMPVDKKVREKLLSDGDILED----------VSML---GRVCKV 594

  Fly   966 RRQV-ALENLQNQRMDNLEQDVPVEFECCFCTTKDFKEFTDAEGVISLP------TSDFHKPICL 1023
            .||| ::|:..:..:|...|.:.             |..:.|....|||      .||:...: |
Zfish   595 ERQVQSIESKLDSLLDIYRQVLQ-------------KGSSTALTFSSLPPFGLEENSDYQSTV-L 645

  Fly  1024 EMRLAAAGRQAGAYGLLSPLPAPLPPLHGPLLALPPPPPLPPTSCAAVLLP----AISQSSSTSS 1084
            ...|:.|          |.:...:...|             |.:...:|.|    .::|::||:|
Zfish   646 SKDLSCA----------SQVSQSICGNH-------------PRALQLILAPNELMNLNQNNSTTS 687

  Fly  1085 SYGTTTS-------TTIALPLDVSLRYGATICSSSNFNHNY---NNNFNTTTVGGGGNGTLLFGG 1139
            |.|...:       :|..:|...||.     |.|:..:.:.   .|:|:.:.            |
Zfish   688 SPGLNPASASPFNLSTFQVPSTPSLE-----CPSAQGSPSQILNANSFHCSI------------G 735

  Fly  1140 NYNGSNNNNADLASVDSS----DTYASCQTHPFLSQGDLTADFND--EAC----ALDIDMDNLYI 1194
            ::.........|:|..:|    .|..|...|. .|.|...:|..|  ::|    .:|:.:::..|
Zfish   736 HFPSVGQPPPPLSSTTTSKYQLSTVPSQAGHA-RSMGPTRSDPADYAKSCFRGVGIDLGLNSSMI 799

  Fly  1195 NPLEREQHQGISSSTGF--IVGLPSTNSSG-----GPRAQVKKSASGDTALRNLAAGGVGAGGLS 1252
            ..|:::........:.:  .:.|.|.....     .|.|.|:...|||.          |.|...
Zfish   800 CKLQQKNRPSAKEDSSWRRHISLDSEVEMDPLAPVSPLAPVQGQCSGDR----------GLGKSL 854

  Fly  1253 PLNDVYQSFDVQERGSRVSLNENSVPKHRKTRFQQSFTAMRPSGATGVLGSSVLGGMRPRARFED 1317
            .:.|:.|.          :|....|..|..   |.||       :|.:..|.
Zfish   855 SVQDLIQP----------ALEGVGVDTHSS---QASF-------STSISSSQ------------- 886

  Fly  1318 TKLDDETGGRREGELAGGSGSPAASGSGGLSGQGPKKKRSVFMPGKSLATATKLINQHLFGIQN- 1381
               |...||...|  |||.|                 :..:|:..:.|.|:||..||....:..
Zfish   887 ---DSSAGGIEMG--AGGWG-----------------EADLFISDRDLDTSTKAHNQGFDFLSQA 929

  Fly  1382 ----------------VGAKAKFESKHSSSIDSIDASPNLEHHR 1409
                            .||.....|.|:|:..| :.:.|:.|.|
Zfish   930 PIDASYSSELLRTSTAAGASHSLASGHTSNTGS-NETINMPHVR 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585
		BTB_2	309..408	CDD:280393
		Ion_trans	501..700	CDD:278921	61/213 (29%)
		Ion_trans_2	613..696	CDD:285168	32/84 (38%)
kcnq5b	XP_697081.4	Ion_trans	145..343	CDD:278921	61/210 (29%)
		Ion_trans_2	259..333	CDD:285168	30/75 (40%)
		KCNQ_channel	443..625	CDD:281513	34/225 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810