Protein Alignment Shab and kcnb2b

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_695259.4
• Gene: kcnb2b / 566883
• ZFINID: ZDB-GENE-091113-38
• Length: 831
• Species: Danio rerio
• Alignment Length: 800
• Identity: 383/800 - (47%)
• Similarity: 503/800 - (62%)
• Gaps: 125/800 - (15%)

  Fly   267 GVPTHSQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHT 331
            |||            :...||:||: ||||..|.::||.:.||.|||||:.||||||||:|||.|
Zfish     8 GVP------------KPGGRSVSSL-PPEPIEIIRTKARSRRVRINVGGLNHEVLWRTLDRLPRT 59

  Fly   332 RLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLE 396
            |||:||:|.||::::|:||||.|.:|||||||||.:|:||||||||||||:::|||.|:|..:|:
Zfish    60 RLGKLRDCNTHDSLMEVCDDYCLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELD 124

  Fly   397 YWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRD-EEEFGEGKCAEYQKYLWELLEKPNT 460
            |||:||:|||||||.:|||:||.::||:|:|||:||:|: |.||....|.|.:|.||||||||::
Zfish   125 YWGIDEIYLESCCQARYHQKKEQMNEELRREAETLREREGEGEFDNTCCPEKRKKLWELLEKPSS 189

  Fly   461 SFAARVIAVISILFIVLSTIALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFS 524
            |.||:::|:||||||||||:||:|||||:||..|. |...||||||.||||||.|||:||:|||.
Zfish   190 SVAAKILAIISILFIVLSTVALSLNTLPELQVTDEFGQANDNPQLAHVEAVCIAWFTMEYLLRFL 254

  Fly   525 ASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARH 589
            :||:|||||||.||:|||||||||:|::||.|:||:.. |||:||||||:|||||||||||||||
Zfish   255 SSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARH 318

  Fly   590 STGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTV 654
            ||||||||||||.||.|||||:||||||::|||||.:||||||..|||.|||.:||||.||||||
Zfish   319 STGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTV 383

  Fly   655 GYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREG 719
            |||||||.|.|||::|.:|||.||||||||||||||||:||||.|.|:|||:||||||:||||.|
Zfish   384 GYGDIYPQTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNG 448

  Fly   720 SIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGH-NLSQT 783
            ||||   :|||||||:||:|:||.|:....                 ::..|...:|.. .:.|.
Zfish   449 SIVS---MNLKDAFARSMELMDVTVEKSDD-----------------KRLTDNHLSPSRWGIPQR 493

  Fly   784 DGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYS-FDNPNARQTS 847
            ..:.|...|...:.| .:|:   :.|.|:.:.::.|..|.....::......:| ....|:.|.:
Zfish   494 TSSDTSLRSFDKKFP-NSGS---QEYVHMPSPQHLNAQNLEEMYNQMTKTQSFSDLSTSNSTQPA 554

  Fly   848 MMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVAT 912
            :::......|.:.:....:||.::                        ..:..|.:.|:..:.|:
Zfish   555 VVSKHEVELEMKEVPTAVKQQPKE------------------------RTITDVRSISSVDSFAS 595

  Fly   913 AT-------NASNASNTA--------------------PGSEGAEGGGDGDGGGV---DDDNLSQ 947
            .|       .|:..|:||                    |.....|     :..|:   |.|:|::
Zfish   596 CTAEFGQGEKATTPSHTAEQFQQRLPKVSPQLHLGQLTPSDLSPE-----ENSGIVNRDTDDLNE 655

  Fly   948 ----------------AKGLPIQMMITPGEVAELRRQVALENLQNQRMDN--LEQDVPVEFECC- 993
                            ||||.:..:.|| |.|.|   ........|.::|  ||.|.| |.||.
Zfish   656 FVENIRSSIRGTNPIKAKGLKVNFIETP-EDAPL---TPPNTSSPQDINNSLLEDDSP-EGECSP 715

  Fly   994 FCTTKDFKEFTDAEGVISLP 1013
            .|:..:.......||::..|
Zfish   716 LCSDSETVGGNSMEGLVLSP 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	73/107 (68%)
		Ion_trans	464..700	CDD:459842	180/236 (76%)
kcnb2b	XP_695259.4	BTB_POZ_KCNB2	19..145	CDD:349719	84/126 (67%)
		Ion_trans	193..429	CDD:459842	180/236 (76%)
		Kv2channel	480..706	CDD:397541	43/262 (16%)