DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shab and KCNK12

DIOPT Version :10

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_071338.1 Gene:KCNK12 / 56660 HGNCID:6274 Length:430 Species:Homo sapiens


Alignment Length:396 Identity:83/396 - (20%)
Similarity:126/396 - (31%) Gaps:127/396 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   597 GFTLRNSYKELGL----LMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYG 657
            |.||||.....|:    |..||..   ..::||.....|....:: ..|..|::.|..::|:|:|
Human    73 GATLRNFSAAHGVAEPELRAFLRH---YEAALAAGVRADALRPRW-DFPGAFYFVGTVVSTIGFG 133

  Fly   658 DIYPTTALGKVI----GTVCCICGVLVIALPIPIIVNNFAEFYKNQMR--REKALKRREALDRAK 716
            ...|.|..||..    |...|...:|...|.:..|::..|..    ||  ||:.|:|...|....
Human   134 MTTPATVGGKAFLIAYGLFGCAGTILFFNLFLERIISLLAFI----MRACRERQLRRSGLLPATF 194

  Fly   717 REGSIVS------------FHHINLKDAFA--------------KSMDLIDVI---------VDT 746
            |.||.:|            :|.:.:...||              :..|.:|.:         :..
Human   195 RRGSALSEADSLAGWKPSVYHVLLILGLFAVLLSCCASAMYTSVEGWDYVDSLYFCFVTFSTIGF 259

  Fly   747 GKQTNVVHPKGKRQSTPNIG-----------------------RQTLDVQ-------------SA 775
            |...:..|...:.|....:|                       :|.|:..             .|
Human   260 GDLVSSQHAAYRNQGLYRLGNFLFILLGVCCIYSLFNVISILIKQVLNWMLRKLSCRCCARCCPA 324

  Fly   776 PGHNLSQTDGNSTEGESTSGRNPATTGTGCYKNY-----DHVANLRNSNLHNRRGSSSEQDAVPP 835
            ||..|::             ||..|.|:...:..     |..|  |:|:...||.|         
Human   325 PGAPLAR-------------RNAITPGSRLRRRLAALGADPAA--RDSDAEGRRLS--------- 365

  Fly   836 YSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGG-GVANN-L 898
                   ....||..:.:..:...||||:|..:...............||..|..|. |:.|| |
Human   366 -------GELISMRDLTASNKVSLALLQKQLSETANGYPRSVCVNTRQNGFSGGVGALGIMNNRL 423

  Fly   899 AMVAAS 904
            |..:||
Human   424 AETSAS 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB_POZ_Shab-like 306..414 CDD:349720
Ion_trans 464..700 CDD:459842 28/110 (25%)
KCNK12NP_071338.1 ER retention/retrieval signal. /evidence=ECO:0000269|PubMed:24163367 11..16
Ion_trans_2 100..169 CDD:462301 17/69 (25%)
Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789 129..134 2/4 (50%)
Ion_trans_2 222..304 CDD:462301 8/81 (10%)
Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789 256..261 0/4 (0%)
Blue background indicates that the domain is not in the aligned region.

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