DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shab and Kcnd3

DIOPT Version :9

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_064315.1 Gene:Kcnd3 / 56543 MGIID:1928743 Length:655 Species:Mus musculus


Alignment Length:681 Identity:201/681 - (29%)
Similarity:315/681 - (46%) Gaps:115/681 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   294 PEPFMIA-QSKAVNSRVSINVGGVRHEVLWR-TLERLPHTRLGRLRECTTHEAIVELCDDYSLAD 356
            |.|...| ::|..:..:.:||.|.|.:. || ||||.|.|.||     :|.:...     ::...
Mouse    26 PMPLAPADKNKRQDELIVLNVSGRRFQT-WRTTLERYPDTLLG-----STEKEFF-----FNEDT 79

  Fly   357 NEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVH 421
            .||||||.|:.|..:||||||||||.....|:.|:.|:|.::|:....:..||..:|..||    
Mouse    80 KEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRK---- 140

  Fly   422 EEMRKEAESLRQRDEEEFGEGK--CAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTL 484
               |:.||.|...::.|..:..  ...:::.:|...|.|:||..|.|...::..||.:|.|...:
Mouse   141 ---RENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVV 202

  Fly   485 NTLPQLQHIDNGTPQDNPQLA----------MVEAVCITWFTLEYILRFSASPDKWKFFKGGLNI 539
            .|:|      .||...:.:|.          .::..|:..||:||:||..|:|.:::|.:..::|
Mouse   203 ETVP------CGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSI 261

  Fly   540 IDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSY 604
            ||::||:||::.|.:  ||.      :||.......|:.|:.||.|.:|||.||:.||:||::..
Mouse   262 IDVVAIMPYYIGLVM--TNN------EDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCA 318

  Fly   605 KELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVI 669
            .|||.|:..|.|.::||:::.::|||....:||.|||.:||:..:||||:||||:.|.|..||:.
Mouse   319 SELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIF 383

  Fly   670 GTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK---ALKRREALDRAKREGSIVSFHHINLKD 731
            |::|.:.||||||||:|:||:||:..|....|.:|   ..|.|.|..|..:.||..::.|.....
Mouse   384 GSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNG 448

  Fly   732 AFAKSMDLIDVIVD--TGKQTNVVHPK-----------------------GKRQSTPNIGRQTLD 771
            ...::::|.....:  .||.|:::..:                       ..|.||.. ..:.:|
Mouse   449 LLNEALELTGTPEEEQMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIK-NHEFID 512

  Fly   772 VQSAPGHNLSQTDGN--STEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVP 834
            .|....:.:..:..|  ||...|.|..:..|| |.|.:......:|.||||              
Mouse   513 EQMFEQNCMESSMQNYPSTRSPSLSSHSGLTT-TCCSRRSKKTTHLPNSNL-------------- 562

  Fly   835 PYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLA 899
                  |..|..||       :|...|..|..:|.........:..||.:        |:..|..
Mouse   563 ------PATRLRSM-------QELSTLHIQGSEQPSLTTSRSSLNLKADD--------GLRPNCK 606

  Fly   900 MVAASSAATAVAT--ATNASNASNTAPGSEG 928
            ....::|..::.|  |......|...|.|.|
Mouse   607 TSQITTAIISIPTPPALTPEGESRPPPASPG 637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB 309..416 CDD:197585 41/107 (38%)
BTB_2 309..408 CDD:280393 38/99 (38%)
Ion_trans 501..700 CDD:278921 83/208 (40%)
Ion_trans_2 613..696 CDD:285168 41/82 (50%)
Kcnd3NP_064315.1 Interaction with KCNIP2. /evidence=ECO:0000250 2..20
BTB_POZ_KCND3 6..143 CDD:349726 48/134 (36%)
Ion_trans 182..412 CDD:366146 93/243 (38%)
Selectivity filter. /evidence=ECO:0000250 367..372 3/4 (75%)
DUF3399 442..563 CDD:371777 24/142 (17%)
Mediates dendritic targeting. /evidence=ECO:0000250 472..487 0/14 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 523..565 15/62 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..655 6/23 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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