DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and kcns3a

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001122196.1	Gene:	kcns3a / 565375	ZFINID:	ZDB-GENE-080723-45	Length:	499	Species:	Danio rerio

Alignment Length:	530	Identity:	203/530 - (38%)
Similarity:	316/530 - (59%)	Gaps:	72/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 QRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAI 345
            |..|.|.     |.|.|           :::||||.:.:|....|:|.|||||.||..|::..||
Zfish     5 QFLHRRG-----PEESF-----------INLNVGGFKQQVERVVLQRFPHTRLARLLYCSSEAAI 53

  Fly   346 VELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQ 410
            ::|||||:.||.||:|||:|..|..:||||.|||:|:::|:||.:||.:|||||:.||:|::||.
Zfish    54 LQLCDDYAAADREYYFDRNPCFFRYVLNFYHTGKIHLMEELCVFSFSQELEYWGIKELHLDTCCS 118

  Fly   411 HKYHQRKENVHE-----------------EMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKP 458
            :::.::|||:.:                 :...|..|...:|.|:|....|||.:|.||..||.|
Zfish   119 NRFQEQKENMGDPDWGNEDDPQNQLQDSLDSSMEELSAFDKDLEKFEGTWCAEKRKELWLRLENP 183

  Fly   459 NTSFAARVIAVISILFIVLSTIALTLNTLPQLQHID-NGTPQDNPQLAMVEAVCITWFTLEYILR 522
            ..|.:|:::||.|:..:::|.||:.::::|:....| |....:||.|.:.|..|:.||:||:|:|
Zfish   184 GYSRSAKILAVFSLSVVLISIIAMCIHSMPEFHQKDANEKEVENPVLDVFETFCVLWFSLEFIVR 248

  Fly   523 FSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLA 587
            ...:|...||....||:||..:|:|::.:|...:.:...:::.::|.||||:.|:|||.||||||
Zfish   249 LVVTPCLRKFICNALNMIDFASIVPFYATLAFEKVDPEESEELENVGRVVQILRLMRIFRILKLA 313

  Fly   588 RHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMT 652
            |||.||:|||.|||:||.|:|||:|||::|:.|||.|.||.|:::.:::..:||..:|||.|:||
Zfish   314 RHSVGLRSLGATLRHSYHEVGLLILFLSVGISIFSVLIYFVEREDHESELQTIPVGWWWATISMT 378

  Fly   653 TVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKR 717
            ||||||.||.|..||:|||:|.|||:||:||||.||.|.|:::|    :|:|||...:.|.....
Zfish   379 TVGYGDTYPVTLPGKLIGTLCIICGLLVVALPISIIFNKFSKYY----QRQKALVESDQLQTEDE 439

  Fly   718 EGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQ 782
            :...:|...:::.|.:::.|:            ::.|....|.|
Zfish   440 KQPDLSMPFLHIADLYSQKMN------------SLAHSASSRSS--------------------- 471

  Fly   783 TDGNSTEGES 792
             :|::|:..|
Zfish   472 -EGDATDASS 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	54/106 (51%)
		BTB_2	309..408	CDD:280393	52/98 (53%)
		Ion_trans	501..700	CDD:278921	101/198 (51%)
		Ion_trans_2	613..696	CDD:285168	46/82 (56%)
kcns3a	NP_001122196.1	BTB_2	17..116	CDD:308049	52/98 (53%)
kcns3a	NP_001122196.1	Ion_trans	189..426	CDD:306908	112/240 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920