Protein Alignment Shab and KCNQ5

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001153605.1
• Gene: KCNQ5 / 56479
• HGNCID: 6299
• Length: 951
• Species: Homo sapiens
• Alignment Length: 778
• Identity: 159/778 - (20%)
• Similarity: 272/778 - (34%)
• Gaps: 252/778 - (32%)

  Fly   443 KCAEYQKYLWELLEKPNTSFAARVIAVISILFIVL----STIALTLNTLPQLQHIDNGTPQDNPQ 503
            |....|.||:.:||:|      |..|.|...|:.|    ..|....:|:|  :|    |...:..
Human   107 KYRRVQNYLYNVLERP------RGWAFIYHAFVFLLVFGCLILSVFSTIP--EH----TKLASSC 159

  Fly   504 LAMVEAVCITWFTLEYILR-FSAS--------PDKWKFFKGGLNIIDLLAILPYFVSLFLLETNK 559
            |.::|.|.|..|.||:|:| :||.        ..:.:|.:....:||.:.::. .:::...:|..
Human   160 LLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIA-SIAVVSAKTQG 223

  Fly   560 N--ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFS 622
            |  ||...:.:       |.::|||::::.|.....:.||..:....||| :...::...|||||
Human   224 NIFATSALRSL-------RFLQILRMVRMDRRGGTWKLLGSVVYAHSKEL-ITAWYIGFLVLIFS 280

  Fly   623 S-LAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIP 686
            | |.|..||| .:.:|.:..:..||..||:||:||||..|.|.||:::.....:.|:...|||..
Human   281 SFLVYLVEKD-ANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAG 344

  Fly   687 IIVNNFAEFYKNQMRREKALKRRE-------------ALDRAKREGSIVSFH-HINL-------- 729
            |:.:.||...:.|.|::...|||.             |.|  ::..||.::. |:..
Human   345 ILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAAD--EKSVSIATWKPHLKALHTCSPTK 407

  Fly   730 -------KDAFAKSMDLIDVIVDTGKQTNVVHPKGK-RQSTPNIGRQTLDVQSAPGHNLSQTDGN 786
                   ...|..:...:..:..:.||:..:..|.: |.::|. |:.....|::.|...|.:...
Human   408 KEQGEASSSKFCSNKQKLFRMYTSRKQSQKLSFKERVRMASPR-GQSIKSRQASVGDRRSPSTDI 471

  Fly   787 STEGEST----------------------SGRNP---ATTGTGCYKNYDHVANLRNSNLHNRRGS 826
            :.||..|                      |...|   |.|..|            ..::::.:|.
Human   472 TAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALG------------TDDVYDEKGC 524

  Fly   827 S---SEQDAVPPYSFDNPNARQTSMMAMESYRR---------EQQALLQQQQQQQQQML-QMQQI 878
            .   |.:|..||.   ....|...:|.....:|         :.:.:::|.......|| :::.:
Human   525 QCDVSVEDLTPPL---KTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSL 586

  Fly   879 QQKAPN--GNGGATGGGVANNLAMVAASSAATAVATATNASNASNTAPGSEGAEGGGDGDGGGVD 941
            |.:...  |.|            .:.:...:....||.:.:.
Human   587 QTRVDQILGKG------------QITSDKKSREKITAEHETT----------------------- 616

  Fly   942 DDNLSQAKGLPIQMMITPGEVAELRRQV-ALENLQNQRMDNLEQ---------------DVPVEF 990
             |:||..           |.|.::.:|| ::|:..:..:|..:|               .:| .|
Human   617 -DDLSML-----------GRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIP-PF 668

  Fly   991 ECCFCTTKDFKEFTDAEGVISLPTSDFHKPI-------------CLEMRLAAAGRQAGAYGLLSP 1042
            ||                   ..|||:..|:             ||. |..:|....|...:|:|
Human   669 EC-------------------EQTSDYQSPVDSKDLSGSAQNSGCLS-RSTSANISRGLQFILTP 713

  Fly  1043 -------LPAPLPPLHGPLLALP----------------------PPPPLPPTSCAAVLLPAI 1076
                   ..|..|.:|.....:|                      |.|..|.|......||||
Human   714 NEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAI 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	71/251 (28%)
KCNQ5	NP_001153605.1	Ion_trans	126..358	CDD:459842	70/247 (28%)
		Interaction with CALM. /evidence=ECO:0000269|PubMed:29429937	370..378		0/7 (0%)
		KCNQ_channel	466..653	CDD:460954	35/248 (14%)
		Interaction with CALM. /evidence=ECO:0000269|PubMed:29429937	540..547		1/6 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	674..697		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	895..938