DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and kcnc3b

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	XP_021325878.1	Gene:	kcnc3b / 564371	ZFINID:	ZDB-GENE-100901-2	Length:	658	Species:	Danio rerio

Alignment Length:	655	Identity:	201/655 - (30%)
Similarity:	300/655 - (45%)	Gaps:	136/655 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 NSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSS 370
            :.::.||.||||||....||:.||.|||..|.|.......     ||....:|:||||||..||.
Zfish    35 SEKIVINCGGVRHETYRSTLKTLPGTRLSWLTEPDAFSNF-----DYDPKSDEFFFDRHPSVFSF 94

  Fly   371 ILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRD 435
            |||:|||||||..:::|...|.::|.:||:||..:|:||...|.|     |.:..:..:|....:
Zfish    95 ILNYYRTGKLHCPNDVCGPLFEEELAFWGIDETDVEACCWMNYRQ-----HRDAEEALDSFETPE 154

  Fly   436 EEE-------FGEGK----CAE-----------YQKYLWELLEKPNTSFAARVIAVISILFIVLS 478
            .|.       .|:|.    |.:           ::..:|.|.|.|.:|..||.:|..|:|||::|
Zfish   155 PEVPDDDPALAGDGDLKRLCLQEDGRKAGWWRVWRPRIWALFEDPYSSKYARYVAFGSLLFILIS 219

  Fly   479 TIALTLNTLPQLQHIDNGTPQ----------------DNPQLAMVEAVCITWFTLEYILRFSASP 527
            .....:.|......|.|.|..                .:..|..||.||:.|||:|...|....|
Zfish   220 ISTFCMETHEAFNTIYNKTENVTEGNVTREEIVYEVVTDSWLTYVEGVCVVWFTIEVFTRVVFCP 284

  Fly   528 DKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTG 592
            ||.:|||..|||||.:|:||:::.:.|...:..|.   :||...::|.|.:|||||.||.||..|
Zfish   285 DKMEFFKSPLNIIDFVAVLPFYLEVGLSGLSSKAA---KDVLGFLRVVRFVRILRIFKLTRHFVG 346

  Fly   593 LQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEK-----DE----KDTKFVSIPETFWWAG 648
            |:.||.|||.|..|..||::|||:|||||:::.|:||:     |:    ..|.|.:||..||||.
Zfish   347 LRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGASPDDPTASAHTNFKNIPIGFWWAV 411

  Fly   649 ITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALD 713
            :||||:||||:||.|..|.::|.:|.:.|||.||:|:|:|||||..:|...|.::|..|::.
Zfish   412 VTMTTLGYGDMYPETWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKN--- 473

  Fly   714 RAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPN------IGRQTLDV 772
                       .||                           |:..:..:||      :...|...
Zfish   474 -----------KHI---------------------------PRAPQPGSPNYCKPDALAMATASP 500

  Fly   773 QSAPGHNLSQTDGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSS---SEQDAVP 834
            |...|:.|....|:|           ..|| .|....:.:..:...:..|...:|   :.:|...
Zfish   501 QRILGNVLGGVLGSS-----------GLTG-DCPLAQEEIIEINRDSKQNGDAASAALANEDCPT 553

  Fly   835 PYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLA 899
            .....:|:.|.......|.|::::...|...::.:..              :|....|.|.:.:.
Zfish   554 IDQVLSPDERSPVGRTQERYQQDRACFLLNTREFRPT--------------DGNVRKGCVISRVC 604

  Fly   900 MVAAS 904
            |:|:|
Zfish   605 MLASS 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	49/106 (46%)
		BTB_2	309..408	CDD:280393	46/98 (47%)
		Ion_trans	501..700	CDD:278921	97/207 (47%)
		Ion_trans_2	613..696	CDD:285168	46/91 (51%)
kcnc3b	XP_021325878.1	Potassium_chann	1..29	CDD:314363
		BTB_2	38..132	CDD:308049	46/98 (47%)
		Ion_trans	205..463	CDD:306908	109/260 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920