DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shab and kcng2

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	XP_690900.2	Gene:	kcng2 / 562421	ZFINID:	ZDB-GENE-100701-1	Length:	546	Species:	Danio rerio

Alignment Length:	486	Identity:	174/486 - (35%)
Similarity:	275/486 - (56%)	Gaps:	41/486 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 INVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFY 375
            |||||:|:.:.|.|||..|.||||||..|...|.|::|||||....||:||||.|.:|.||:.|.
Zfish    74 INVGGIRYRIPWSTLEEFPLTRLGRLHNCNNAEEILDLCDDYDARCNEFFFDRSPSAFRSIVTFL 138

  Fly   376 RTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMR---KEAESLRQRDEE 437
            ..|||.::.|||.|:|.::|.||||:|..||.||..|...|:|...|.:|   :|||.......|
Zfish   139 AAGKLRLLREMCALSFQEELSYWGVEEASLEWCCLRKLRLRQEEQRERLRLEEEEAELTSPHSCE 203

  Fly   438 EF------GEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHID-- 494
            |.      .||:.:.....|.:::|.|::....::.|.:|::|:.::.:.|.::|:|.|:..:
Zfish   204 EAPAVGSPEEGRLSGCMHSLRDMVENPHSGIPGKIFACLSVVFVAITAVTLCVSTMPDLREEEER 268

  Fly   495 NGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETN- 558
            ....|....:.::|.||:.||:||::|||..:..|..|.:..|||||::|||||:::|.:...:
Zfish   269 GECSQRCYNIFVLETVCVGWFSLEFLLRFIQTQSKCTFLRTPLNIIDVVAILPYYITLIVDSMSV 333

  Fly   559 -----KNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGV 618
                 .:..:..:.|..|::|.|.:||..:::|||||.|||:||.|:|...:|.|||:|||.:.:
Zfish   334 GDRPAGSGNNYLEKVGLVLRVLRALRIFYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLCVAM 398

  Fly   619 LIFSSLAYFAEKD-EKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIA 682
            .:||.|.:.||.: ....:|.|||.::|||.|:||||||||:.|.:..|:|:.....:.|:|::|
Zfish   399 ALFSPLVFLAESELGAKQEFTSIPGSYWWAVISMTTVGYGDMVPRSIPGQVVALSSILSGILLMA 463

  Fly   683 LPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTG 747
            .|:..|.:.|:..|         |:.:|..:||.|       |..:.:|: .||.:..| ..||.
Zfish   464 FPVTSIFHTFSRSY---------LELKEEQNRATR-------HKPDSQDS-TKSQNSED-SQDTD 510

  Fly   748 KQTNVVHPKGKRQSTPNIGRQTLDV--QSAP 776
            ..   :|...:..:...:.|:::.|  |.||
Zfish   511 SS---IHGITETTAVSALHRRSVAVASQGAP 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	55/104 (53%)
		BTB_2	309..408	CDD:280393	52/96 (54%)
		Ion_trans	501..700	CDD:278921	79/205 (39%)
		Ion_trans_2	613..696	CDD:285168	32/83 (39%)
kcng2	XP_690900.2	BTB	72..172	CDD:197585	52/97 (54%)
		BTB_2	73..171	CDD:280393	52/96 (54%)
		Ion_trans	273..481	CDD:278921	81/216 (38%)
		Ion_trans_2	<416..475	CDD:285168	25/58 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910