DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shab and kcnv1

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	XP_688404.1	Gene:	kcnv1 / 559915	ZFINID:	ZDB-GENE-100922-109	Length:	485	Species:	Danio rerio

Alignment Length:	462	Identity:	192/462 - (41%)
Similarity:	296/462 - (64%)	Gaps:	38/462 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 SMSSIPPPEP--FMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELC 349
            |..::|..:|  |.|           |||||.|:.:....|...|.||||:| ..::.::.::||
Zfish    28 SEPALPTDDPLEFFI-----------INVGGSRYILSQELLASHPETRLGKL-ALSSRDSALDLC 80

  Fly   350 DDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYH 414
            ||....:|||||||:.::|..|:|||:||.||:.:|:||::|..::||||:|||.::|||:.||:
Zfish    81 DDADFLENEYFFDRNSQTFQYIMNFYKTGHLHVREELCVISFLQEIEYWGIDELRIDSCCRDKYY 145

  Fly   415 QRKENVHE-EMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLS 478
            :|||.... ::||:|: :..::||:|....|.:.::.||:::|.|::|.||:....:|:.|:|:|
Zfish   146 RRKEMKESLDIRKDAD-VMDKEEEDFTGVLCQDLRQRLWDIMENPDSSKAAKTFGTLSMFFVVVS 209

  Fly   479 TIALTLNTL-------PQLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGG 536
            .:.:.|.:|       |.:             |.::|.:||.|||.|.:|||....||.||.:..
Zfish   210 IVNMALISLDFSVIGAPII-------------LDILEYICIIWFTGELVLRFLCVRDKCKFSRSV 261

  Fly   537 LNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLR 601
            :||||||||||::|:| .:|:....:.:.::|.|||||.|:||.||:|||.||||||:|||.|:.
Zfish   262 VNIIDLLAILPFYVTL-AVESLHGESTELENVGRVVQVLRLMRSLRMLKLGRHSTGLKSLGLTIA 325

  Fly   602 NSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALG 666
            ..|:|:|||||||::|:.||::|.|..|.|..:|.|.::|..:|||..:|||||||||.|.||:|
Zfish   326 QCYEEVGLLMLFLSVGISIFATLEYAIEHDTPETTFTNVPSAWWWATTSMTTVGYGDIRPDTAVG 390

  Fly   667 KVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKR-EGSIVSFHHINLK 730
            ||:..:|.:.|:|::||||.||.:.|:..|.....:|.||:..|.|.|..| ..|.:|...:||:
Zfish   391 KVMAFICILSGILILALPIAIINDRFSACYFTLKMKEAALRHGEVLKRLTRSSASDMSAIGVNLR 455

  Fly   731 DAFAKSM 737
            |.:|:|:
Zfish   456 DVYARSV 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	49/106 (46%)
		BTB_2	309..408	CDD:280393	44/98 (45%)
		Ion_trans	501..700	CDD:278921	100/198 (51%)
		Ion_trans_2	613..696	CDD:285168	40/82 (49%)
kcnv1	XP_688404.1	BTB	42..141	CDD:197585	47/110 (43%)
		BTB_2	42..139	CDD:280393	45/108 (42%)
		Ion_trans	226..420	CDD:278921	100/207 (48%)
		Ion_trans_2	337..417	CDD:285168	39/79 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920