Protein Alignment Shab and kcna4

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_005169005.1
• Gene: kcna4 / 559036
• ZFINID: ZDB-GENE-121127-2
• Length: 667
• Species: Danio rerio
• Alignment Length: 624
• Identity: 206/624 - (33%)
• Similarity: 303/624 - (48%)
• Gaps: 124/624 - (19%)

  Fly   157 AGLVSRHLDYG-------------DGGHLAGPSAGLPAGAVGSGAGA---------GAGAGASVT 199
            :|..:.||.||             :....|..:|...|||||.|.|:         .:.|.:|..
Zfish    10 SGGCNTHLPYGYAQARARERERERERHSRAAAAAAAEAGAVGEGGGSTGHPHNHPHQSRAASSTN 74

  Fly   200 GSGSGAGTGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSIPTTSQQIV---GSVGGV------- 254
            .:.|.|||.:...:.|.|......::.::         |..|   ||::   ....||
Zfish    75 ANNSSAGTASRPSSSSSSQQPQQQQQQQH---------HEPP---QQLLRERKKQRGVARWRRNR 127

  Fly   255 -GVGGASSQS---ISGG---VPTHSQSNTTGALQRTHSRSMS--------------SIPPPEPFM 298
             .:||...||   :.|.   :....:....|..:....:|..              |:....|
Zfish   128 AALGGDLRQSELALLGSEEDIMIEEEEEAEGEEEEEDRKSKRSSFVYNMDDEEETVSLTDRRP-- 190

  Fly   299 IAQSKAVN--------SRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLA 355
              ||...|        .||.|||.|::.|...:||.:.|.|.||...:.:.:         :...
Zfish   191 --QSGYENVYNEYGCCERVVINVSGLKFETQLKTLAQFPDTLLGDPEKRSRY---------FDPL 244

  Fly   356 DNEYFFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGV-DELYLESCCQHKYHQRKE 418
            .|||||||:..||.:||.||:: |:|.....:....||::::::.: ||..|      |:.:.:.
Zfish   245 RNEYFFDRNRPSFDAILYFYQSGGRLKRPVNVPFDIFSEEVKFYELGDEAML------KFREDEG 303

  Fly   419 NVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALT 483
            .|.||.:...|.               |:::.:|.|.|.|.:|..||.|||:|:|.||:|.:...
Zfish   304 FVKEEEKPLPED---------------EFKRQIWLLFEYPESSSPARGIAVVSVLVIVISIVIFC 353

  Fly   484 LNTLPQLQ-------------HIDNG-TPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFK 534
            |.|||:.:             ..||| ||.::| ..:||.|||.||:.|.|:||.|||.|..|||
Zfish   354 LETLPEFRDDKEFLIPGKNSTQADNGFTPFNDP-FFIVETVCIIWFSFEIIVRFFASPSKADFFK 417

  Fly   535 GGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFT 599
            ..:|.||:::|||||::|......:....|......::::.|::|:.||.||:|||.|||.||.|
Zfish   418 NVMNTIDIVSILPYFITLGTDLAQQQGNGQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHT 482

  Fly   600 LRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTA 664
            ||.|.:||.||:.||.:||::|||..||||.||..::|.|||:.||||.:|||||||||:.|.|.
Zfish   483 LRASMRELALLIFFLVIGVILFSSAVYFAEADEPTSQFTSIPDAFWWAVVTMTTVGYGDMKPITV 547

  Fly   665 LGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRRE 703
            .||::|::|.|.|||.||||:|:||:||..||..:...|
Zfish   548 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDNE 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	35/117 (30%)
		Ion_trans	464..700	CDD:459842	121/249 (49%)
kcna4	XP_005169005.1	K_channel_TID	1..>21	CDD:429748	4/10 (40%)
		BTB_POZ	205..331	CDD:453885	43/155 (28%)
		Ion_trans	382..582	CDD:459842	103/200 (52%)