DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shab and kcns3b

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001032460.1	Gene:	kcns3b / 558674	ZFINID:	ZDB-GENE-051120-78	Length:	424	Species:	Danio rerio

Alignment Length:	421	Identity:	173/421 - (41%)
Similarity:	270/421 - (64%)	Gaps:	27/421 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 VSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILN 373
            |::|:||:.|:|....|.|.||||:.:|.:|.:..||:|||||||..:.||:|||.|:.|..:||
Zfish    17 VNLNIGGIHHKVERCVLLRFPHTRVAQLIQCHSDAAILELCDDYSPTEQEYYFDRSPQVFHCVLN 81

  Fly   374 FYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEE 438
            |||||..|.::|:||..||.::||||:.||.|::||...:.:||:  ..|:....:|.:.....|
Zfish    82 FYRTGHFHTLEELCVFCFSQEIEYWGLCELDLDACCLEWFLERKD--EHELNSSGQSSKNASSGE 144

  Fly   439 F---------GEG-KCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHI 493
            .         .|| :|::.:|.:||.||.|..|..:|.:|.:|:|.|::|.:|:.:::||:.::.
Zfish   145 ISVTSEDLWKSEGMRCSDVRKLMWETLEDPQHSRCSRGVAAVSVLVILISILAMCVHSLPEFRYQ 209

  Fly   494 DNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLF---LL 555
            .:|   ::..|..||..||.:|::|:.||..|:|...:|....||:||:.:|||::::|.   |.
Zfish   210 TDG---EHSVLDSVELFCIVFFSVEFFLRVIAAPQPLRFLGNPLNMIDVASILPFYITLAVERLD 271

  Fly   556 ETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLI 620
            |.:|.......::.|||||.|:||..|:|||||||.|:::.|.||.|...|:|||:||:.:|:..
Zfish   272 EEDKEENQSLVNMGRVVQVLRLMRSFRVLKLARHSEGMRAFGETLMNCQCEVGLLVLFITVGISF 336

  Fly   621 FSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPI 685
            ||:..|:.||:|..::..|||..:||..|:||||||||:||.|..|:::.|||.:||:|||:|||
Zfish   337 FSTFIYYTEKEEASSQLSSIPICWWWGIISMTTVGYGDVYPLTVAGRIVATVCILCGLLVISLPI 401

  Fly   686 PIIVNNFAEFYKNQMRREKALKRREALDRAK 716
            .||:|||:::::         |.|:.|..||
Zfish   402 TIIMNNFSKYFE---------KNRKCLSEAK 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	52/106 (49%)
		BTB_2	309..408	CDD:280393	50/98 (51%)
		Ion_trans	501..700	CDD:278921	91/201 (45%)
		Ion_trans_2	613..696	CDD:285168	42/82 (51%)
kcns3b	NP_001032460.1	BTB	17..117	CDD:197585	50/99 (51%)
		BTB_2	17..116	CDD:280393	50/98 (51%)
		Ion_trans	205..414	CDD:278921	92/220 (42%)
		Ion_trans_2	329..410	CDD:285168	42/80 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101602
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820