DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shab and kcnq1.1

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001116714.1	Gene:	kcnq1.1 / 557498	ZFINID:	ZDB-GENE-061214-5	Length:	655	Species:	Danio rerio

Alignment Length:	463	Identity:	113/463 - (24%)
Similarity:	197/463 - (42%)	Gaps:	95/463 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 QKYLWELLEKPNTSFAARVIAVISILFIVLSTIALT-LNTLPQLQHIDNGTPQDNPQLAMVEAVC 511
            |..::..||:| |.:...|.. .::..||||.:.|: |:|:.:.|.:.|.|      |..:|.|.
Zfish    75 QGRVYNFLERP-TGWKCFVYH-FTVFLIVLSCLILSVLSTIDEYQALANKT------LFWMELVL 131

  Fly   512 ITWFTLEYILRFSASP---------DKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQD 567
            :.:|.:||::|..::.         .:.:|.:..:::|||:.::   .|:.:|....|.
Zfish   132 VMFFGVEYVVRLWSAGCRSKYVGILGRLRFARKPISVIDLIVVV---ASIIVLAFGSNG------ 187

  Fly   568 VRRVVQVF--------RIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS- 623
                 |||        |.::|||:|.:.|.....:.||..:....:|| :..|::....|||||
Zfish   188 -----QVFATSAVRGVRFLQILRMLHVDRQGGTWRLLGSVVFIHRQEL-ITTLYIGFLGLIFSSY 246

  Fly   624 LAYFAEKDEKD----TKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALP 684
            ..|.||||..|    :.|.|..:..||..:|:||:||||..|.|.:||.|.:...:..:...|||
Zfish   247 FVYLAEKDAVDDHGNSGFGSYADALWWGVVTVTTIGYGDKVPQTWIGKTIASCFSVFAISFFALP 311

  Fly   685 IPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQ 749
            ..|:.:.|| ....|.:|:|...|:.....:..:.|...|..:|...|..|      :.|.....
Zfish   312 AGILGSGFA-LKVQQKQRQKHFNRQIPAAASLIQASWRCFALLNPDSATYK------LFVKRNLS 369

  Fly   750 TNVVHPKGK--------------RQSTPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSG--RNP 798
            ::...||.|              .|::|.:...|.|         |..||..:..|:.:.  ::.
Zfish   370 SSGSSPKLKVKMRRKMKISDRNNGQNSPAVPSITYD---------SFDDGRDSRQETLTSLQQSV 425

  Fly   799 ATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYS----FD---NPNARQTSMMA--MESY 854
            .:.||...:.|:...:..:        .||.|.:.||.:    |:   .|..:::|.:|  ||:.
Zfish   426 ISDGTNTTRRYERAPSWNS--------LSSFQFSTPPATKPGVFEVSSRPTLQRSSSIADDMETE 482

  Fly   855 RREQQALL 862
            ...:..|:
Zfish   483 PEREIVLI 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585
		BTB_2	309..408	CDD:280393
		Ion_trans	501..700	CDD:278921	61/220 (28%)
		Ion_trans_2	613..696	CDD:285168	33/87 (38%)
kcnq1.1	NP_001116714.1	Ion_trans	121..327	CDD:278921	64/227 (28%)
		Ion_trans_2	238..317	CDD:285168	31/78 (40%)
		KCNQ_channel	<503..>561	CDD:281513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810