DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and kcnb2a

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	XP_005163503.1	Gene:	kcnb2a / 555921	ZFINID:	ZDB-GENE-070912-170	Length:	824	Species:	Danio rerio

Alignment Length:	795	Identity:	376/795 - (47%)
Similarity:	482/795 - (60%)	Gaps:	142/795 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 SRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELC 349
            ||...|: ||||..|.::||.:.||.|||||:.||||||||:|||.||||:||:|.|||.::|:|
Zfish    13 SRPQGSL-PPEPIDIIRTKARSRRVRINVGGLVHEVLWRTLDRLPRTRLGKLRDCNTHETLMEIC 76

  Fly   350 DDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYH 414
            |||||.||||||||||.:||||||||||||||:::|||.|:|..:|:|||:||:|||||||.:||
Zfish    77 DDYSLNDNEYFFDRHPGAFSSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYH 141

  Fly   415 QRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLST 479
            |:||.::||:|:|||:||:::.::...|.|.:.::.||:|||||::|.||:|:|:||||||:|||
Zfish   142 QKKEQMNEELRREAETLREKEGDQVDTGCCPDKRQKLWDLLEKPSSSVAAKVLAIISILFIILST 206

  Fly   480 IALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLL 543
            |||:|||||:||.||. |...|||.||.||||||.|||:||:|||.:||:|||||||.||:||||
Zfish   207 IALSLNTLPELQVIDEFGQSNDNPNLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLL 271

  Fly   544 AILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELG 608
            |||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.||.|||
Zfish   272 AILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELG 335

  Fly   609 LLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVC 673
            ||:||||||::|||||.:||||||..|||.|||.:||||.|||||||||||||.|.|||::|.:|
Zfish   336 LLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPQTLLGKIVGGLC 400

  Fly   674 CICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMD 738
            ||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :|||||||::|:
Zfish   401 CIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNLKDAFARNME 462

  Fly   739 LIDVIVDTGKQ---TNVVHP-KGKRQSTPN-----------------------IGRQTLDVQSAP 776
            |:||:::..:.   .|.:.| :...|..||                       :.|.|...|...
Zfish   463 LLDVVIEKNEDKAADNHLSPSRWNYQKNPNSELGSKGFDSKYQEVGQLASPERVFRSTPSPQRLN 527

  Fly   777 GHNLSQTDGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNR---------RGSSS---- 828
            ..:|.|.....|...|.|...|:.:........:....::......|         |..||
Zfish   528 AKSLEQMYNQMTAASSMSSSGPSASKVSTVVGREEEMEMKVVQCEPRLKEKPVTEIRSLSSVDSF 592

  Fly   829 ----------EQDA-VPPYSFDNPNA---RQTSMMAMESYRREQQALLQQ--------------- 864
                      |:.| :|.::..:|.|   ...|.:.....|.:|..::::
Zfish   593 ASCATDISEVERSALLPNFAGRHPRAPPPLDLSQITSLEKRAKQPTIIKEGLYEFVPCKSDGSST 657

  Fly   865 --QQQQQQQMLQMQQIQQKAPNGN------------GGATGGGVANNLAMVAASSAAT------- 908
              |.::.|...|..:..:..|.||            ..|..|  |:||.:|.....||
Zfish   658 MSQGEENQSFDQSDENVRSPPQGNQVKLKGLKVNFTESAEEG--ASNLHLVVTDDVATLTPKVPV 720

  Fly   909 --------------------------------------------AVATATNASNASNTAPGSEGA 929
                                                        |..|.|:..:|.|.|..:.||
Zfish   721 SDPLLLAGSPRQSPRATEGDGATSSPGFSLSSSESQRGRNHVDRAAVTPTSPKSAQNCASATAGA 785

  Fly   930 EGGGDGDGGGVDDDN 944
            .|..|....|...||
Zfish   786 VGAEDNIQSGQKVDN 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	78/106 (74%)
		BTB_2	309..408	CDD:280393	72/98 (73%)
		Ion_trans	501..700	CDD:278921	155/198 (78%)
		Ion_trans_2	613..696	CDD:285168	64/82 (78%)
kcnb2a	XP_005163503.1	BTB	36..142	CDD:197585	77/105 (73%)
		BTB_2	36..135	CDD:280393	72/98 (73%)
		Ion_trans	229..427	CDD:278921	155/198 (78%)
		Ion_trans_2	340..421	CDD:285168	63/80 (79%)
		Kv2channel	473..695	CDD:281514	32/221 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I911
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	662	1.000	Inparanoid score	I737
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002877
OrthoInspector	1	1.000	-	-		otm25945
orthoMCL	1	0.900	-	-		OOG6_101602
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.860