Protein Alignment Shab and kcnb2a

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_683673.2
• Gene: kcnb2a / 555921
• ZFINID: ZDB-GENE-070912-170
• Length: 824
• Species: Danio rerio
• Alignment Length: 795
• Identity: 376/795 - (47%)
• Similarity: 482/795 - (60%)
• Gaps: 142/795 - (17%)

  Fly   285 SRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELC 349
            ||...|: ||||..|.::||.:.||.|||||:.||||||||:|||.||||:||:|.|||.::|:|
Zfish    13 SRPQGSL-PPEPIDIIRTKARSRRVRINVGGLVHEVLWRTLDRLPRTRLGKLRDCNTHETLMEIC 76

  Fly   350 DDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYH 414
            |||||.||||||||||.:||||||||||||||:::|||.|:|..:|:|||:||:|||||||.:||
Zfish    77 DDYSLNDNEYFFDRHPGAFSSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYH 141

  Fly   415 QRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLST 479
            |:||.::||:|:|||:||:::.::...|.|.:.::.||:|||||::|.||:|:|:||||||:|||
Zfish   142 QKKEQMNEELRREAETLREKEGDQVDTGCCPDKRQKLWDLLEKPSSSVAAKVLAIISILFIILST 206

  Fly   480 IALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLL 543
            |||:|||||:||.||. |...|||.||.||||||.|||:||:|||.:||:|||||||.||:||||
Zfish   207 IALSLNTLPELQVIDEFGQSNDNPNLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLL 271

  Fly   544 AILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELG 608
            |||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.||.|||
Zfish   272 AILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELG 335

  Fly   609 LLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVC 673
            ||:||||||::|||||.:||||||..|||.|||.:||||.|||||||||||||.|.|||::|.:|
Zfish   336 LLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPQTLLGKIVGGLC 400

  Fly   674 CICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMD 738
            ||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :|||||||::|:
Zfish   401 CIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNLKDAFARNME 462

  Fly   739 LIDVIVDTGKQ---TNVVHP-KGKRQSTPN-----------------------IGRQTLDVQSAP 776
            |:||:::..:.   .|.:.| :...|..||                       :.|.|...|...
Zfish   463 LLDVVIEKNEDKAADNHLSPSRWNYQKNPNSELGSKGFDSKYQEVGQLASPERVFRSTPSPQRLN 527

  Fly   777 GHNLSQTDGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNR---------RGSSS---- 828
            ..:|.|.....|...|.|...|:.:........:....::......|         |..||
Zfish   528 AKSLEQMYNQMTAASSMSSSGPSASKVSTVVGREEEMEMKVVQCEPRLKEKPVTEIRSLSSVDSF 592

  Fly   829 ----------EQDA-VPPYSFDNPNA---RQTSMMAMESYRREQQALLQQ--------------- 864
                      |:.| :|.::..:|.|   ...|.:.....|.:|..::::
Zfish   593 ASCATDISEVERSALLPNFAGRHPRAPPPLDLSQITSLEKRAKQPTIIKEGLYEFVPCKSDGSST 657

  Fly   865 --QQQQQQQMLQMQQIQQKAPNGN------------GGATGGGVANNLAMVAASSAAT------- 908
              |.::.|...|..:..:..|.||            ..|..|  |:||.:|.....||
Zfish   658 MSQGEENQSFDQSDENVRSPPQGNQVKLKGLKVNFTESAEEG--ASNLHLVVTDDVATLTPKVPV 720

  Fly   909 --------------------------------------------AVATATNASNASNTAPGSEGA 929
                                                        |..|.|:..:|.|.|..:.||
Zfish   721 SDPLLLAGSPRQSPRATEGDGATSSPGFSLSSSESQRGRNHVDRAAVTPTSPKSAQNCASATAGA 785

  Fly   930 EGGGDGDGGGVDDDN 944
            .|..|....|...||
Zfish   786 VGAEDNIQSGQKVDN 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	77/107 (72%)
		Ion_trans	464..700	CDD:459842	181/236 (77%)
kcnb2a	XP_683673.2	BTB_POZ_KCNB2	18..144	CDD:349719	88/126 (70%)
		Ion_trans	206..427	CDD:459842	170/221 (77%)
		Kv2channel	473..695	CDD:397541	32/221 (14%)