Protein Alignment Shab and kcnb1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_682848.4
• Gene: kcnb1 / 555284
• ZFINID: ZDB-GENE-090831-3
• Length: 834
• Species: Danio rerio
• Alignment Length: 742
• Identity: 368/742 - (49%)
• Similarity: 476/742 - (64%)
• Gaps: 118/742 - (15%)

  Fly   277 TGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTT 341
            :..:.:..|||.:|: ||||..|.:|.:...||.:||||:.||||||||:|||.||||:||:|.|
Zfish     5 SAGMSKVGSRSTASL-PPEPVDIIRSMSCYRRVKLNVGGLPHEVLWRTLDRLPRTRLGKLRDCKT 68

  Fly   342 HEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLE 406
            ||:::|:||||:|.||||||||||.:|:||||||||||||:::|||.|:||.:|:||||||:|||
Zfish    69 HESLMEVCDDYNLEDNEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFSQELDYWGVDEIYLE 133

  Fly   407 SCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVIS 471
            ||||.:|||:||.::||:::||::|:.|:.|||....|:|.:|.||:|||||.:|.||:::|:||
Zfish   134 SCCQARYHQKKEQMNEELKREADTLKDREGEEFDNTCCSEKRKKLWDLLEKPGSSVAAKILAIIS 198

  Fly   472 ILFIVLSTIALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKG 535
            |||||||||||:|||||:||..|. |...||.|||.||||||.|||:||:|||.:||:|||||||
Zfish   199 ILFIVLSTIALSLNTLPELQETDEFGQTTDNTQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKG 263

  Fly   536 GLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTL 600
            .||:|||||||||:|::||.|:||:.. |||:||||||:||||||||||||||||||||||||||
Zfish   264 PLNVIDLLAILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTL 327

  Fly   601 RNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTAL 665
            |.||.|||||:||||||::|||||.:||||||.||||.|||.:||||.|||||||||||||.|.|
Zfish   328 RRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLL 392

  Fly   666 GKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLK 730
            ||::|.:|||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :|::
Zfish   393 GKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNVR 454

  Fly   731 DAFAKSMDLIDVIV-DTGKQTNVVH-----------------------------PKGKRQSTP-N 764
            :||::..||:||:| |.|:::...|                             |...|.|:| .
Zfish   455 EAFSRGTDLLDVVVMDKGERSQDNHLSPSRWKWSSKRGTSETSSNRSFNPDQGSPSKARASSPQR 519

  Fly   765 IGRQTLD--------VQSAPGHNLSQTDGNSTEG-----ESTSGRNPATTGTGCYKNYDHVANLR 816
            :..|.|:        .||.|  ||:..|.||:..     |...|..|...|.......:.|.:::
Zfish   520 LNAQKLEDMYNQMAKTQSQP--NLNTKDRNSSRAGHRRDEIELGALPGQGGDPMNGGREGVVDMK 582

  Fly   817 -----------------NSNLHNR------------------RGSSSEQDA-------------- 832
                             |...|..                  .|.||...|
Zfish   583 SLSSIDSYISCATDFQENPRFHYSPAGGLSLPESSRFSHSPGSGLSSRVSANPSLQTTLEHETML 647

  Fly   833 VPPYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANN 897
            .||:|...|         :.:....||.||...|:.....:..:...:.:|      :||.::::
Zfish   648 TPPFSGAKP---------LNTDGSRQQGLLGNSQKMHSVRVNPRNCAESSP------SGGPLSDS 697

  Fly   898 LAMVAASSAATAVATATNASNASNTAP 924
            ..:...|..:..|:..|.||  :.|.|
Zfish   698 SILSDHSILSPEVSVYTTAS--TRTPP 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	76/107 (71%)
		Ion_trans	464..700	CDD:459842	181/236 (77%)
kcnb1	XP_682848.4	BTB_POZ_KCNB1	25..141	CDD:349718	78/115 (68%)
		Ion_trans	191..427	CDD:459842	181/236 (77%)
		Kv2channel	470..712	CDD:397541	42/258 (16%)