Protein Alignment Shab and Kcnk6

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001028697.2
• Gene: Kcnk6 / 52150
• MGIID: 1891291
• Length: 313
• Species: Mus musculus
• Alignment Length: 187
• Identity: 40/187 - (21%)
• Similarity: 70/187 - (37%)
• Gaps: 47/187 - (25%)

  Fly   524 SASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQ-VFRIMRI-LRILKL 586
            :||...|.|           |...:|.|..:.......|....|..:... ||.::.: :.:|.|
Mouse    85 NASDPAWDF-----------ASALFFASTLVTTVGYGYTTPLTDAGKAFSIVFALLGVPITMLLL 138

  Fly   587 ARHSTGLQSLGFTLRNS------------------YKELGLLMLFLAMGVLIFSSLAYFAEKDEK 633
               :...|.|...|.::                  :..:.|||:.:|:..|:  ..|.||..:|.
Mouse   139 ---TASAQRLSLLLTHAPLSWLSLHWGWPPQRAARWHLVALLMVIVAIFFLV--PAAVFAYLEEA 198

  Fly   634 DTKFVSIPETFWWAGITMTTVGYGDIYPTTALG-------KVIGTVCCICGVLVIAL 683
                .|..:.|::..|:::|:|.||..|..|.|       ||:.|.....|::.:.|
Mouse   199 ----WSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTAYLFLGLVAMVL 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	40/187 (21%)
Kcnk6	NP_001028697.2	Ion_trans_2	<89..146	CDD:462301	12/70 (17%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111		0/4 (0%)
		Ion_trans_2	180..259	CDD:462301	21/78 (27%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219		2/4 (50%)
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	282..290
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	308..312