Protein Alignment Shab and KCNS3

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_002243.3
• Gene: KCNS3 / 3790
• HGNCID: 6302
• Length: 491
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 192/462 - (41%)
• Similarity: 299/462 - (64%)
• Gaps: 28/462 - (6%)

  Fly   309 VSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILN 373
            |::||||.:..|...||.|.||||||:|..|.:.|||:|||||||:||.||:|||:|..|..:||
Human    17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLN 81

  Fly   374 FYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHE------------EMRK 426
            ||.|||||:::|:||.:|..::||||::||:::|||.::|.:|||..||            :...
Human    82 FYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSF 146

  Fly   427 EAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQ 491
            |..||.:::.|:|...:..:.:|.:|..:|.|....:|::||:.|:..::.|.:|:.::::.:.|
Human   147 EESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQ 211

  Fly   492 HIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLE 556
            :.|...  |:|.|..||..||.|||.|..:|.:|:|.:.||:|..|||||.::|:|::.:| .::
Human   212 NEDGEV--DDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATL-AVD 273

  Fly   557 TNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIF 621
            |.:..::..:::.:|||:.|:|||.|||||||||.||:|||.|||:||.|:|||:|||::|:.||
Human   274 TKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIF 338

  Fly   622 SSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIP 686
            |.|.|..|||:..:...|||..:|||.|:||||||||.:|.|..||:|.:.|.|||:||:||||.
Human   339 SVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPIT 403

  Fly   687 IIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAK-------SMDLIDVIV 744
            ||.|.|:::|:.|...:......:|.::..      ...:.|::|.:|:       |:..:.::|
Human   404 IIFNKFSKYYQKQKDIDVDQCSEDAPEKCH------ELPYFNIRDIYAQRMHTFITSLSSVGIVV 462

  Fly   745 DTGKQTN 751
            .....|:
Human   463 SDPDSTD 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	58/104 (56%)
		Ion_trans	464..700	CDD:459842	111/235 (47%)
KCNS3	NP_002243.3	BTB_POZ_KCNS3	15..122	CDD:349735	58/104 (56%)
		Ion_trans	184..417	CDD:459842	111/235 (47%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		4/4 (100%)