Protein Alignment Shab and KCNS2

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 190/451 - (42%)
• Similarity: 284/451 - (62%)
• Gaps: 25/451 - (5%)

  Fly   299 IAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDR 363
            ::::...:..:.|||||.:..:...||.|.|.||||||..|.:.|||:||||||.....|::|||
Human     9 VSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDR 73

  Fly   364 HPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEA 428
            :|:.|..:|:||.|||||::.|:||.:||.::||||::|.:::|||.:.||.||  |..|..|..
Human    74 NPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRK--VEPEQEKWD 136

  Fly   429 ESLRQ--------------RDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLST 479
            |...|              .|..:|.......:::.||..|:.|..|..:||.:::|||.::.|.
Human   137 EQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSI 201

  Fly   480 IALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLL 543
            |.:.||:||..|..|: |.|.::|:..:||...|.|||.|.:.||:.:||..||||..||:|||:
Human   202 ITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLM 266

  Fly   544 AILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELG 608
            :|:|::::| ::.....:|....::.||.||.|:|||.||||||||||||:|||.||:.||||:|
Human   267 SIVPFYITL-VVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVG 330

  Fly   609 LLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVC 673
            ||:|:|::|:.|||.:||..||:|.: ...:||..:|||.::||||||||:.|.|..||:..:.|
Human   331 LLLLYLSVGISIFSVVAYTIEKEENE-GLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASAC 394

  Fly   674 CICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFA 734
            .:.|:||:.|||.:|.|.|:.||:.|.:.|.|::..:..|..|...|      :||:|.:|
Human   395 ILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPS------VNLRDYYA 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	52/107 (49%)
		Ion_trans	464..700	CDD:459842	112/236 (47%)
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	52/105 (50%)
		Ion_trans	186..421	CDD:459842	112/236 (47%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)