DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and KCNS1

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	XP_016883335.1	Gene:	KCNS1 / 3787	HGNCID:	6300	Length:	527	Species:	Homo sapiens

Alignment Length:	518	Identity:	188/518 - (36%)
Similarity:	300/518 - (57%)	Gaps:	47/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 SSQSISGGVPTHSQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRT 324
            ||:..|.|.|..:...:.|   |:....:|..|.|:..:  :.:..:..:.:||||||.::..|.
Human     9 SSRKGSPGTPQRALLVSAG---RSTETFVSEFPGPDTGI--RWRRSDEALRVNVGGVRRQLSARA 68

  Fly   325 LERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVL 389
            |.|.|.||||||:...:.|....|||||..|..|::|||||..|.|:|:|||||.||::||:||.
Human    69 LARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVF 133

  Fly   390 AFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAE------------SLRQRDEEEFGEG 442
            ||..:.:|||:.|..|.:||:.:|.:|:........::::            |..||:...:|..
Human   134 AFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAA 198

  Fly   443 KCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHID----------NGT 497
            :|...::.||..:|.|..|..:::.:.:||..::.|..|:.:::||:.|..:          ..:
Human   199 RCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRS 263

  Fly   498 PQ---DNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFL-LETN 558
            |:   |:|.|..:|..||.||:.|...|...:|....||...||:||::::||::::|.. :...
Human   264 PEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALG 328

  Fly   559 KNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS 623
            .....:|..:.:||||||:|||.|:||||||||||:|||.||::||:|:|:|:|:||:||.:||.
Human   329 DQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSG 393

  Fly   624 LAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPII 688
            :||.|||:| |..|.:||..:||..::||||||||:.|.|..||:..:.|.:.|:||:||||.||
Human   394 VAYTAEKEE-DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITII 457

  Fly   689 VNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTN 751
            .|.|:.||    ||:|||           |.::.:.:|...:|..:....:.:..::|.::|:
Human   458 FNKFSHFY----RRQKAL-----------EAAVRNSNHQEFEDLLSSIDGVSEASLETSRETS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	53/106 (50%)
		BTB_2	309..408	CDD:280393	50/98 (51%)
		Ion_trans	501..700	CDD:278921	95/199 (48%)
		Ion_trans_2	613..696	CDD:285168	42/82 (51%)
KCNS1	XP_016883335.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920