DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and KCNQ3

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_004510.1	Gene:	KCNQ3 / 3786	HGNCID:	6297	Length:	872	Species:	Homo sapiens

Alignment Length:	857	Identity:	176/857 - (20%)
Similarity:	305/857 - (35%)	Gaps:	219/857 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 KCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIAL-TLNTLPQLQHIDNGTPQDNPQLAM 506
            |....|..:::.||:|. .:|....|:  :..|||..:.| .|.|..:.:.:      ....|.:
Human   103 KYRRIQTLIYDALERPR-GWALLYHAL--VFLIVLGCLILAVLTTFKEYETV------SGDWLLL 158

  Fly   507 VEAVCITWFTLEYILRFSASP--DKWKFFKGG----------LNIIDLLAILPYFVSLFLLETNK 559
            :|...|..|..|:.||..|:.  .::|.::|.          |:|..|:|.:|  |.....:.|.
Human   159 LETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVP--VVAVGNQGNV 221

  Fly   560 NATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKEL------GLLMLFLAMGV 618
            .||.        ::..|.::|||:|::.|.....:.||..:....|||      |.|.|.|:
Human   222 LATS--------LRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILS--- 275

  Fly   619 LIFSSLAYFAEKD---------EKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCC 674
               |.|.|..|||         |...:|.:..:..||..||:.|:||||..|.|..|::|.....
Human   276 ---SFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFS 337

  Fly   675 ICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRR----EALDRAKR-----------------E 718
            :.||...|||..|:.:..|...:.|.|::...|||    |.:..|.|                 .
Human   338 LIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFY 402

  Fly   719 GSIVSFHHI---NLKDAFAKSMDLID-VIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHN 779
            .|:|||...   .|:.|.::.:.|:| |.:...:.:|.   |||..:..|:..    ::.:|...
Human   403 ESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNT---KGKLFTPLNVDA----IEESPSKE 460

  Fly   780 LSQTDGNSTEGESTSGRNPA--------TTGTGCYKNYDHVANLRNSNLHNRRGSSSE---QDAV 833
            ......|:.|...|:.|..|        ..|||     |.:|        ..||..::   :|.:
Human   461 PKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTG-----DPMA--------EDRGYGNDFPIEDMI 512

  Fly   834 PPYSFDNPNARQTSMMAMESYRR---------EQQALLQQQQQQQQQML-QMQQIQQKAPNGNGG 888
            |..   ....|...::....|::         :.:.:::|.......|| :::.:|.:
Human   513 PTL---KAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR------- 567

  Fly   889 ATGGGVANNLAMVAASSAATAVATATNASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPI 953
                     :.|:......:......:...::.|.|..:...          ::..:::.....|
Human   568 ---------IDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPR----------NEPYVARPSTSEI 613

  Fly   954 QMMITPGEVAELRRQVA--------LENLQNQRMDNLEQDV-----------PVEFECCFCTTKD 999
            :.....|:..::.|||.        |.::..|.|:.|:..|           |.|.|     .|:
Human   614 EDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAE-----KKE 673

  Fly  1000 FKEFTDAEGVI--------SLPTSDFHKPICLEMRLAAAGRQAGAYGLLSPLPAPLP---PLHGP 1053
            ...::|.:.:|        ..|...||: :.::        :...||..:..|..||   |..|.
Human   674 DNRYSDLKTIICNYSETGPPEPPYSFHQ-VTID--------KVSPYGFFAHDPVNLPRGGPSSGK 729

  Fly  1054 LLALPP---------PPPLP-------PTSC--AAVLLPAISQSSSTSSSYGTTTSTTIALPLDV 1100
            :.|.||         |..||       ..||  .|.|....|...|.......|..:...|.| :
Human   730 VQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRRSITRDSDTPLSL-M 793

  Fly  1101 SLRYGATICSSSNFNHNYNNNFNTTTVGGGGNGTLLFGGNYNGSNNNNADLASVDSSDTYASCQT 1165
            |:.:.....|.|.|  :.:.:.:....|..|..:.:....|......:.|      :|.:....:
Human   794 SVNHEELERSPSGF--SISQDRDDYVFGPNGGSSWMREKRYLAEGETDTD------TDPFTPSGS 850

  Fly  1166 HPFLSQGDLTAD 1177
            .|..|.||..:|
Human   851 MPLSSTGDGISD 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585
		BTB_2	309..408	CDD:280393
		Ion_trans	501..700	CDD:278921	62/225 (28%)
		Ion_trans_2	613..696	CDD:285168	29/91 (32%)
KCNQ3	NP_004510.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Ion_trans	139..363	CDD:278921	65/245 (27%)
		Ion_trans_2	269..353	CDD:285168	30/89 (34%)
		Selectivity filter. /evidence=ECO:0000250	316..321		3/4 (75%)
		Mediates interaction with calmodulin. /evidence=ECO:0000269\|PubMed:27564677	356..537		40/203 (20%)
		KCNQ_channel	452..656	CDD:281513	34/249 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..611		2/45 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..872		21/108 (19%)
		KCNQC3-Ank-G_bd	780..866	CDD:288784	17/92 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810