DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shab and KCNQ2

DIOPT Version :9

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_001369164.1 Gene:KCNQ2 / 3785 HGNCID:6296 Length:890 Species:Homo sapiens


Alignment Length:902 Identity:190/902 - (21%)
Similarity:319/902 - (35%) Gaps:281/902 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   448 QKYLWELLEKPNTSFAARVIAVI---SILFIVLSTIALTL-NTLPQLQHIDNGTPQDNPQLAMVE 508
            |.:|:.:||:|      |..|.|   .:..:|.|.:.|:: :|:.:.:....|.      |.::|
Human    78 QNFLYNVLERP------RGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGA------LYILE 130

  Fly   509 AVCITWFTLEYILRFSAS---------PDKWKFFKGGLNIIDLLAILPYFVSLFLL----ETNKN 560
            .|.|..|.:||.:|..|:         ..:.||.:....:||::.::   .|:.:|    :.|..
Human   131 IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLI---ASIAVLAAGSQGNVF 192

  Fly   561 ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKEL------GLLMLFLAMGVL 619
            ||...:.:       |.::|||::::.|.....:.||..:....|||      |.|.|.||    
Human   193 ATSALRSL-------RFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILA---- 246

  Fly   620 IFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALP 684
              |.|.|.|||.|.| .|.:..:..||..||:||:||||.||.|..|:::.....:.||...|||
Human   247 --SFLVYLAEKGEND-HFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALP 308

  Fly   685 IPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVS---FHHINLKDAFAKS---------- 736
            ..|:.:.||...:.|.|::...|||.     ...|.|.|   |:..||......|          
Human   309 AGILGSGFALKVQEQHRQKHFEKRRN-----PAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVT 368

  Fly   737 MDLIDVIVDTGKQTNVVHPKGKRQSTPNIG-------RQTLDVQSAPGHNLSQTDG--NSTEGES 792
            :.:......|...:.::.|..:.:...|:.       |:....:.:|...:|..|.  :|..|.:
Human   369 VPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSQKVSLKDRVFSSPRGVA 433

  Fly   793 TSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQ------DAVP-PYSF-DNPNARQT-SM 848
            ..|:......|                  .||..|::|      ..|| .:|| |...|||. .:
Human   434 AKGKGSPQAQT------------------VRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRI 480

  Fly   849 MAMESYRREQQALLQQQ------------------------------------QQQQQQMLQ--- 874
            ....|.:..::|.|..:                                    :::.::.|:   
Human   481 KGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYD 545

  Fly   875 -MQQIQQKAPNGNGGATGGGVANNLAMVA-ASSAATAVATATNASNASN-----------TAPGS 926
             |..|:|.:            |.:|.|:: ..|..:.:.........|.           |||..
Human   546 VMDVIEQYS------------AGHLDMLSRIKSLQSRIDMIVGPPPPSTPRHKKYPTKGPTAPPR 598

  Fly   927 EGAEGGGD-----GDGGGVDDDNLSQAKG-----LP--IQMMITPGEVAELRRQVA--------L 971
            |..:....     |.|..:.|.:  :.||     ||  ..||   |.:.::.:||.        |
Human   599 ESPQYSPRVDQIVGRGPAITDKD--RTKGPAEAELPEDPSMM---GRLGKVEKQVLSMEKKLDFL 658

  Fly   972 ENLQNQRMDNLEQDVPVEFECCF-----------CTTKDFKEFTDAEGVISLPTSDFHKPICLEM 1025
            .|:..|||.    ..|.|.|..|           .:.:|.:|..|..|.|              :
Human   659 VNIYMQRMG----IPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCI--------------V 705

  Fly  1026 RLAAAGRQAGAYGLLSPLPAP---LPPL--------------------HGPLLALPPPPPLPPTS 1067
            ::..:....|.....:|..||   .||.                    ||.|:.:||||....: 
Human   706 KIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERS- 769

  Fly  1068 CAAVLLPAISQSSSTSSSYGTTTSTTIALPLDVSLRYGATICSSSNFNH-NYNNNFNTTTVGGGG 1131
                 |.|....:..|..:.....|....|.:.:||...|..|..:.:| ....:|:        
Human   770 -----LSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFS-------- 821

  Fly  1132 NGTLLFGGNYNGSNNN----NADLASVDSSDTYASC-QTHPFLSQGDLTADFNDEAC 1183
                  |.:.:.|..|    |:..|:|      |.| :..|::::|:  :|.:.:.|
Human   822 ------GFSISQSKENLDALNSCYAAV------APCAKVRPYIAEGE--SDTDSDLC 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB 309..416 CDD:197585
BTB_2 309..408 CDD:280393
Ion_trans 501..700 CDD:278921 64/217 (29%)
Ion_trans_2 613..696 CDD:285168 33/82 (40%)
KCNQ2NP_001369164.1 Ion_trans 92..324 CDD:395416 71/254 (28%)
KCNQ_channel 448..669 CDD:397540 43/241 (18%)
KCNQ2_u3 684..774 CDD:406935 20/109 (18%)
KCNQC3-Ank-G_bd 786..886 CDD:403240 20/101 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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