Protein Alignment Shab and KCNQ2

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001369164.1
• Gene: KCNQ2 / 3785
• HGNCID: 6296
• Length: 890
• Species: Homo sapiens
• Alignment Length: 902
• Identity: 190/902 - (21%)
• Similarity: 319/902 - (35%)
• Gaps: 281/902 - (31%)

  Fly   448 QKYLWELLEKPNTSFAARVIAVI---SILFIVLSTIALTL-NTLPQLQHIDNGTPQDNPQLAMVE 508
            |.:|:.:||:|      |..|.|   .:..:|.|.:.|:: :|:.:.:....|.      |.::|
Human    78 QNFLYNVLERP------RGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGA------LYILE 130

  Fly   509 AVCITWFTLEYILRFSAS---------PDKWKFFKGGLNIIDLLAILPYFVSLFLL----ETNKN 560
            .|.|..|.:||.:|..|:         ..:.||.:....:||::.::   .|:.:|    :.|..
Human   131 IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLI---ASIAVLAAGSQGNVF 192

  Fly   561 ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKEL------GLLMLFLAMGVL 619
            ||...:.:       |.::|||::::.|.....:.||..:....|||      |.|.|.||
Human   193 ATSALRSL-------RFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILA---- 246

  Fly   620 IFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALP 684
              |.|.|.|||.|.| .|.:..:..||..||:||:||||.||.|..|:::.....:.||...|||
Human   247 --SFLVYLAEKGEND-HFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALP 308

  Fly   685 IPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVS---FHHINLKDAFAKS---------- 736
            ..|:.:.||...:.|.|::...|||.     ...|.|.|   |:..||......|
Human   309 AGILGSGFALKVQEQHRQKHFEKRRN-----PAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVT 368

  Fly   737 MDLIDVIVDTGKQTNVVHPKGKRQSTPNIG-------RQTLDVQSAPGHNLSQTDG--NSTEGES 792
            :.:......|...:.::.|..:.:...|:.       |:....:.:|...:|..|.  :|..|.:
Human   369 VPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSQKVSLKDRVFSSPRGVA 433

  Fly   793 TSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQ------DAVP-PYSF-DNPNARQT-SM 848
            ..|:......|                  .||..|::|      ..|| .:|| |...|||. .:
Human   434 AKGKGSPQAQT------------------VRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRI 480

  Fly   849 MAMESYRREQQALLQQQ------------------------------------QQQQQQMLQ--- 874
            ....|.:..::|.|..:                                    :::.::.|:
Human   481 KGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYD 545

  Fly   875 -MQQIQQKAPNGNGGATGGGVANNLAMVA-ASSAATAVATATNASNASN-----------TAPGS 926
             |..|:|.:            |.:|.|:: ..|..:.:.........|.           |||..
Human   546 VMDVIEQYS------------AGHLDMLSRIKSLQSRIDMIVGPPPPSTPRHKKYPTKGPTAPPR 598

  Fly   927 EGAEGGGD-----GDGGGVDDDNLSQAKG-----LP--IQMMITPGEVAELRRQVA--------L 971
            |..:....     |.|..:.|.:  :.||     ||  ..||   |.:.::.:||.        |
Human   599 ESPQYSPRVDQIVGRGPAITDKD--RTKGPAEAELPEDPSMM---GRLGKVEKQVLSMEKKLDFL 658

  Fly   972 ENLQNQRMDNLEQDVPVEFECCF-----------CTTKDFKEFTDAEGVISLPTSDFHKPICLEM 1025
            .|:..|||.    ..|.|.|..|           .:.:|.:|..|..|.|              :
Human   659 VNIYMQRMG----IPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCI--------------V 705

  Fly  1026 RLAAAGRQAGAYGLLSPLPAP---LPPL--------------------HGPLLALPPPPPLPPTS 1067
            ::..:....|.....:|..||   .||.                    ||.|:.:||||....:
Human   706 KIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERS- 769

  Fly  1068 CAAVLLPAISQSSSTSSSYGTTTSTTIALPLDVSLRYGATICSSSNFNH-NYNNNFNTTTVGGGG 1131
                 |.|....:..|..:.....|....|.:.:||...|..|..:.:| ....:|:
Human   770 -----LSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFS-------- 821

  Fly  1132 NGTLLFGGNYNGSNNN----NADLASVDSSDTYASC-QTHPFLSQGDLTADFNDEAC 1183
                  |.:.:.|..|    |:..|:|      |.| :..|::::|:  :|.:.:.|
Human   822 ------GFSISQSKENLDALNSCYAAV------APCAKVRPYIAEGE--SDTDSDLC 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	72/258 (28%)
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:459842	71/254 (28%)
		KCNQ_channel	448..669	CDD:460954	43/241 (18%)
		KCNQ2_u3	683..774	CDD:465213	20/110 (18%)
		KCNQC3-Ank-G_bd	786..886	CDD:463411	20/101 (20%)