Protein Alignment Shab and KCNK3

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_002237.1
• Gene: KCNK3 / 3777
• HGNCID: 6278
• Length: 394
• Species: Homo sapiens
• Alignment Length: 221
• Identity: 40/221 - (18%)
• Similarity: 72/221 - (32%)
• Gaps: 90/221 - (40%)

  Fly   504 LAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKN-------- 560
            ||::  ||    |..|:|             .|..:.|.|...|..:....||..:.
Human     9 LALI--VC----TFTYLL-------------VGAAVFDALESEPELIERQRLELRQQELRARYNL 54

  Fly   561 ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLA 625
            :...::::.|||           |:|..|..|:|
Human    55 SQGGYEELERVV-----------LRLKPHKAGVQ------------------------------- 77

  Fly   626 YFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPII-- 688
                     .:|..   :|::|...:||:|||...|:|..|||.   |....:|.|.|.:.:.
Human    78 ---------WRFAG---SFYFAITVITTIGYGHAAPSTDGGKVF---CMFYALLGIPLTLVMFQS 127

  Fly   689 ----VNNFAEFYKNQMRREKALKRRE 710
                :|....:..::.::...::|.:
Human   128 LGERINTLVRYLLHRAKKGLGMRRAD 153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	39/209 (19%)
KCNK3	NP_002237.1	Ion_trans_2	<73..132	CDD:462301	19/104 (18%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:26919430	93..98		3/4 (75%)
		Ion_trans_2	167..243	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:26919430	199..204
		X-gate. /evidence=ECO:0000269|PubMed:32499642	243..248
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..286
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..357