| Sequence 1: | NP_001189037.1 | Gene: | Shab / 38352 | FlyBaseID: | FBgn0262593 | Length: | 1607 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001017425.2 | Gene: | KCNK2 / 3776 | HGNCID: | 6277 | Length: | 426 | Species: | Homo sapiens |
| Alignment Length: | 120 | Identity: | 28/120 - (23%) |
|---|---|---|---|
| Similarity: | 47/120 - (39%) | Gaps: | 48/120 - (40%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 609 LLMLFLAMGVLIFSSLAYFAEKDEKDT------KFVS-------------------------IP- 641
Fly 642 -------------ETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIAL 683 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Shab | NP_001189037.1 | BTB_POZ_Shab-like | 306..414 | CDD:349720 | |
| Ion_trans | 464..700 | CDD:459842 | 28/120 (23%) | ||
| KCNK2 | NP_001017425.2 | Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6 | 17..38 | ||
| Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6 | 51..61 | ||||
| Ion_trans_2 | <138..196 | CDD:462301 | 17/50 (34%) | ||
| Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:Q920B6 | 157..162 | 2/4 (50%) | |||
| Ion_trans_2 | 234..312 | CDD:462301 | |||
| Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q920B6 | 266..271 | ||||
| Interaction with AKAP5. /evidence=ECO:0000250|UniProtKB:P97438 | 313..326 | ||||
| Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250|UniProtKB:P97438 | 337..385 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||