DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shab and KCNF1

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_002227.2	Gene:	KCNF1 / 3754	HGNCID:	6246	Length:	494	Species:	Homo sapiens

Alignment Length:	419	Identity:	180/419 - (42%)
Similarity:	265/419 - (63%)	Gaps:	9/419 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 PEPFMIAQSKAVNSRVSI--NVGGVRHEVLWRTLERLPHTRLGRLRECTT--HEAIVELCDDYSL 354
            |||.  :||.|.:..:.|  ||||||..:....|.:.|.|||..|..|..  ::.|..|||||..
Human    10 PEPG--SQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDP 72

  Fly   355 ADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKEN 419
            ...|::|||.|.:|..::..|..|::|:...:|.:.|.:::::|.||..:|:.||:....:::|.
Human    73 GKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREE 137

  Fly   420 VHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTL 484
            : ||:.:..:.:......:..||:....||.:|:.||||.:|..|||:||:|.|.|::|::.:.:
Human   138 L-EEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCM 201

  Fly   485 NTLPQLQHID-NGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPY 548
            .|:|:||.:| .|...::|.|..||..||.||||||:||..:||:|..|....:||:|:|||||:
Human   202 GTIPELQVLDAEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPF 266

  Fly   549 FVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLF 613
            :|||.|........ :..:|::.||..|||||.||.||||||:|||:|.:.|:.|:||||||:::
Human   267 YVSLTLTHLGARMM-ELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMY 330

  Fly   614 LAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGV 678
            ||:|:.:||:|.|..|:...:|.|.|||::||||.|||||||||||||.|.|||:...:..:|||
Human   331 LAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGV 395

  Fly   679 LVIALPIPIIVNNFAEFYKNQMRREKALK 707
            :.|||||..|:|||..:|..|...|.|.|
Human   396 IAIALPIHPIINNFVRYYNKQRVLETAAK 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	37/110 (34%)
		BTB_2	309..408	CDD:280393	35/102 (34%)
		Ion_trans	501..700	CDD:278921	105/198 (53%)
		Ion_trans_2	613..696	CDD:285168	46/82 (56%)
KCNF1	NP_002227.2	BTB_POZ_Kv5_KCNF1	23..138	CDD:349690	38/114 (33%)
		Ion_trans	181..417	CDD:395416	120/236 (51%)
		Selectivity filter. /evidence=ECO:0000250	370..375		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..469
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920