Protein Alignment Shab and KCND3

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_004971.2
• Gene: KCND3 / 3752
• HGNCID: 6239
• Length: 655
• Species: Homo sapiens
• Alignment Length: 681
• Identity: 200/681 - (29%)
• Similarity: 315/681 - (46%)
• Gaps: 115/681 - (16%)

  Fly   294 PEPFMIA-QSKAVNSRVSINVGGVRHEVLWR-TLERLPHTRLGRLRECTTHEAIVELCDDYSLAD 356
            |.|...| ::|..:..:.:||.|.|.:. || ||||.|.|.||     :|.:...     ::...
Human    26 PMPLAPADKNKRQDELIVLNVSGRRFQT-WRTTLERYPDTLLG-----STEKEFF-----FNEDT 79

  Fly   357 NEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVH 421
            .||||||.|:.|..:||||||||||.....|:.|:.|:|.::|:....:..||..:|..||
Human    80 KEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRK---- 140

  Fly   422 EEMRKEAESLRQRDEEEFGEGK--CAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTL 484
               |:.||.|...::.|..:..  ...:::.:|...|.|:||..|.|...::..||.:|.|...:
Human   141 ---RENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVV 202

  Fly   485 NTLPQLQHIDNGTPQDNPQLA----------MVEAVCITWFTLEYILRFSASPDKWKFFKGGLNI 539
            .|:|      .||...:.:|.          .::..|:..||:||:||..|:|.:::|.:..::|
Human   203 ETVP------CGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSI 261

  Fly   540 IDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSY 604
            ||::||:||::.|.:  ||.      :||.......|:.|:.||.|.:|||.||:.||:||::..
Human   262 IDVVAIMPYYIGLVM--TNN------EDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCA 318

  Fly   605 KELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVI 669
            .|||.|:..|.|.::||:::.::|||....:||.|||.:||:..:||||:||||:.|.|..||:.
Human   319 SELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIF 383

  Fly   670 GTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK---ALKRREALDRAKREGSIVSFHHINLKD 731
            |::|.:.||||||||:|:||:||:..|....|.:|   ..|.|.|..|..:.||..::.|.....
Human   384 GSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNG 448

  Fly   732 AFAKSMDLIDVIVD--TGKQTNVVHPK-----------------------GKRQSTPNIGRQTLD 771
            ...::::|.....:  .||.|:::..:                       ..|.||.. ..:.:|
Human   449 LLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIK-NHEFID 512

  Fly   772 VQSAPGHNLSQTDGN--STEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVP 834
            .|....:.:..:..|  ||...|.|. :|..|.|.|.:......:|.||||
Human   513 EQMFEQNCMESSMQNYPSTRSPSLSS-HPGLTTTCCSRRSKKTTHLPNSNL-------------- 562

  Fly   835 PYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLA 899
                  |..|..||       :|...:..|..:|.........:..||.:        |:..|..
Human   563 ------PATRLRSM-------QELSTIHIQGSEQPSLTTSRSSLNLKADD--------GLRPNCK 606

  Fly   900 MVAASSAATAVAT--ATNASNASNTAPGSEG 928
            ....::|..::.|  |......|...|.|.|
Human   607 TSQITTAIISIPTPPALTPEGESRPPPASPG 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	40/108 (37%)
		Ion_trans	464..700	CDD:459842	93/245 (38%)
KCND3	NP_004971.2	BTB_POZ_KCND3	6..143	CDD:349726	48/134 (36%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:34997220	6..21
		Interaction with KCNIP1. /evidence=ECO:0000269|PubMed:17187064	70..78		0/12 (0%)
		Ion_trans	186..412	CDD:459842	91/239 (38%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	367..372		3/4 (75%)
		DUF3399	468..563	CDD:463381	20/116 (17%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:34997220	470..487		0/16 (0%)
		Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	472..487		0/14 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..565		15/60 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..655		6/23 (26%)