Protein Alignment Shab and KCND2

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_036413.1
• Gene: KCND2 / 3751
• HGNCID: 6238
• Length: 630
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 182/594 - (30%)
• Similarity: 292/594 - (49%)
• Gaps: 63/594 - (10%)

  Fly   288 MSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDD- 351
            ::|.|.|.|....:.:..::.:.:||.|.|.:....||||.|.|.||....            |
Human    22 VASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSER------------DF 74

  Fly   352 -YSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQ 415
             |.....:|||||.|..|..|||||||||||.....|:.|:.::|.::|:....:..||..:|..
Human    75 FYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKD 139

  Fly   416 RKENVHEEMRKEAESLRQRDEEEFGEGKCAEY--QKYLWELLEKPNTSFAARVIAVISILFIVLS 478
            |:....|.::.:|      |.:..||......  ::.:|...|.|:||..|.|...::..||.:|
Human   140 RRRENAERLQDDA------DTDTAGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVS 198

  Fly   479 TIALTLNTLP---QLQHIDNGTPQDNPQLAM--VEAVCITWFTLEYILRFSASPDKWKFFKGGLN 538
            .||..:.|:|   ...||......:...:|.  ::..|:..||:||:||.:|:|.:::|.:..::
Human   199 VIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMS 263

  Fly   539 IIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNS 603
            |||::|||||::.|.:       ||. :||.......|:.|:.||.|.:|||.||:.||:||::.
Human   264 IIDVVAILPYYIGLVM-------TDN-EDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSC 320

  Fly   604 YKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKV 668
            ..|||.|:..|.|.::||:::.::|||....:||.|||..||:..:||||:||||:.|.|..||:
Human   321 ASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKI 385

  Fly   669 IGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK---ALKRREALDRAKREGSIVSFHHIN-- 728
            .|::|.:.||||||||:|:||:||:..|....|.:|   ..|.|.|..||.:.||..::....
Human   386 FGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRN 450

  Fly   729 --LKDAFAKSMDLIDVIVDTG-----KQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDGN 786
              |.:....|.|....:..:|     :..:::|...|..:...:..|..:........:::...:
Human   451 GLLSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSH 515

  Fly   787 STEGESTSGRNPATTGTGCYKNYDHVANLRNSNLH-NRRGSSSEQDAV-------PPYSFDNPNA 843
            |....|..|    .|.|.|.:.:.....:.|:|:. :.:||..|...:       .|.|    |:
Human   516 SPSLSSQQG----VTSTCCSRRHKKTFRIPNANVSGSHQGSIQELSTIQIRCVERTPLS----NS 572

  Fly   844 RQTSMMAME 852
            |.:....||
Human   573 RSSLNAKME 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	38/109 (35%)
		Ion_trans	464..700	CDD:459842	95/240 (40%)
KCND2	NP_036413.1	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881	2..20
		BTB_POZ	6..144	CDD:453885	44/133 (33%)
		Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q63881	71..90		7/30 (23%)
		Ion_trans	184..415	CDD:459842	95/238 (40%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	308..321		6/12 (50%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		3/4 (75%)
		DUF3399	470..546	CDD:463381	12/79 (15%)
		Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250|UniProtKB:Q63881, ECO:0000305|PubMed:16934482	474..630		20/116 (17%)
		Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	474..489		2/14 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	600..630
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q63881	627..630