DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and KCND1

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	XP_024308146.1	Gene:	KCND1 / 3750	HGNCID:	6237	Length:	675	Species:	Homo sapiens

Alignment Length:	679	Identity:	200/679 - (29%)
Similarity:	309/679 - (45%)	Gaps:	122/679 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 PPEPFMIAQSKAVNSR----VSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYS 353
            ||.|.:.|      ||    :.:||.|.|.|....||:|.|.|.||...:...::|
Human    28 PPAPGVKA------SRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDA--------- 77

  Fly   354 LADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKE 418
             ...||||||.|..|..:|||||||:||...:.|:.||.::|.::|:....:..||..:|..||
Human    78 -DSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK- 140

  Fly   419 NVHEEMRKEAESLRQRDE-EEFGEGKC----AEYQKYLWELLEKPNTSFAARVIAVISILFIVLS 478
                  ::.||.|.:.:| |:.|:|..    :..::.||...|.|:||.||.|...::..||.:|
Human   141 ------KENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVS 199

  Fly   479 TIALTLNTLP---------QLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFK 534
            .||..:.|:|         :.|......||   ....::..|:..||.||:||..|:|.:.:|.:
Human   200 VIANVVETIPCRGSARRSSREQPCGERFPQ---AFFCMDTACVLIFTGEYLLRLFAAPSRCRFLR 261

  Fly   535 GGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFT 599
            ..:::||::|||||::.|.:   .||     .||.......|:.|:.||.|.:|||.||:.||:|
Human   262 SVMSLIDVVAILPYYIGLLV---PKN-----DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYT 318

  Fly   600 LRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTA 664
            |::...|||.|:..|.|.::||:::.::|||....|.|.|||..||:..:||||:||||:.|:|.
Human   319 LKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTI 383

  Fly   665 LGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK---ALKRREALDRAKREGSIVSFHH 726
            .||:.|::|.:.||||||||:|:||:||:..|....|.:|   ..|.|.|..|..:.|:..:|..
Human   384 AGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQ 448

  Fly   727 INLKDAF--AKSMD----------------LIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQ 773
            .......  .:.:|                |:.::.|:|        .|:.|:.....|...:.|
Human   449 YKQNGGLEVGRGLDRVGVSHNGEEGAALIALLHLLQDSG--------SGEEQALCVRNRSAFEQQ 505

  Fly   774 SAPGHNLSQ----------TD--------------GNSTEGESTSGR--NPATTGTGC--YKNYD 810
            .   |:|..          ||              |.::...|.|.:  .|.:..:.|  .:...
Human   506 H---HHLLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRRAKR 567

  Fly   811 HVANLRNSNLHNRRGSSSEQDAV-------PPYSFDNPNARQTSMMAMESYRREQQALLQQQQQQ 868
            ....|.||.....|||..|.|.:       .|.|..:.||:....:.:....|:..|.:......
Human   568 RAIRLANSTASVSRGSMQELDMLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRDFVAAIISIPTP 632

  Fly   869 QQQMLQMQQIQQKAPNGNGGATGGGVANN 897
            ...  ...:.|..:| |.||..|..:.|:
Human   633 PAN--TPDESQPSSP-GGGGRAGSTLRNS 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	38/106 (36%)
		BTB_2	309..408	CDD:280393	35/98 (36%)
		Ion_trans	501..700	CDD:278921	82/198 (41%)
		Ion_trans_2	613..696	CDD:285168	41/82 (50%)
KCND1	XP_024308146.1	Shal-type	3..28	CDD:288455	200/679 (29%)
		BTB_2	42..131	CDD:308049	35/98 (36%)
		Ion_trans	185..417	CDD:306908	94/242 (39%)
		DUF3399	447..578	CDD:314709	20/141 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810