Protein Alignment Shab and KCNC3

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_004968.2
• Gene: KCNC3 / 3748
• HGNCID: 6235
• Length: 757
• Species: Homo sapiens
• Alignment Length: 967
• Identity: 251/967 - (25%)
• Similarity: 340/967 - (35%)
• Gaps: 359/967 - (37%)

  Fly   142 PAAGGAAYHLGPANPAGLVSRHLDYGDGGHLAGPSAGLPAGAVGSGAGAGAGAGASVTGSGSGAG 206
            ||..|.|     |:|||..:..   |.|...|.|..||||.|:|...|.|..:|
Human    43 PAQPGPA-----ASPAGPPAPR---GPGDRRAEPCPGLPAAAMGRHGGGGGDSG----------- 88

  Fly   207 TGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGGVPTH 271
                                                                             
Human    89 ----------------------------------------------------------------- 88

  Fly   272 SQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRL 336
                                                ::.|||||||||....||..||.|||..|
Human    89 ------------------------------------KIVINVGGVRHETYRSTLRTLPGTRLAGL 117

  Fly   337 RECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVD 401
               |..||....  ||....:|:||||||..|:.:||:|||||||...::|...|.::|.:||:|
Human   118 ---TEPEAAARF--DYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGID 177

  Fly   402 ELYLESCCQHKYHQRKENVHEEMRKEAESLRQRD------------------EEEFGEG------ 442
            |..:|:||...|.|     |.:..:..:|....|                  ::|.|.|
Human   178 ETDVEACCWMTYRQ-----HRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDG 237

  Fly   443 -------KCAE-----------------------YQKYLWELLEKPNTSFAARVIAVISILFIVL 477
                   .|.:                       :|..:|.|.|.|.:|.|||.:|..|:.||::
Human   238 AGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILI 302

  Fly   478 STIALTLNTLPQLQHIDN----------GTPQDN---------PQLAMVEAVCITWFTLEYILRF 523
            |.....|.|.....||.|          |.|.:|         |.|..||.||:.|||.|:::|.
Human   303 SITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRI 367

  Fly   524 SASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLAR 588
            :..|||.:|.|..|||||.:||||:::.:.|...:..|.   :||...::|.|.:|||||.||.|
Human   368 TFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAA---KDVLGFLRVVRFVRILRIFKLTR 429

  Fly   589 HSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEK---DEKD------TKFVSIPETF 644
            |..||:.||.|||.|..|..||::|||:|||||:::.|:||:   |..|      |.|.:||..|
Human   430 HFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGF 494

  Fly   645 WWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRR 709
            |||.:||||:||||:||.|..|.::|.:|.:.|||.||:|:|:|||||..:|...|.::|..|::
Human   495 WWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKK 559

  Fly   710 EALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQS 774
            .              .||                           |:..:..:||..:.......
Human   560 N--------------KHI---------------------------PRPPQPGSPNYCKPDPPPPP 583

  Fly   775 APGHNLSQTDGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFD 839
            .|                                            |...||..   ..||....
Human   584 PP--------------------------------------------HPHHGSGG---ISPPPPIT 601

  Fly   840 NPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAAS 904
            .|:...|...|..:.......||:                       |||.|.|:.....:.|..
Human   602 PPSMGVTVAGAYPAGPHTHPGLLR-----------------------GGAGGLGIMGLPPLPAPG 643

  Fly   905 SAATAVATATNASNASNTAP-GSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQ 968
            .............|.::..| |...|......|...:|...:|.....|    ||||......|.
Human   644 EPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSP----ITPGSRGRYSRD 704

  Fly   969 VALENLQNQRMDNLEQDVPVEFECCFCTTKDFKEFTD-----AEGVISLPTSDFHKP 1020
            .|                      ||..| |:....|     |.|...||..|:.||
Human   705 RA----------------------CFLLT-DYAPSPDGSIRKATGAPPLPPQDWRKP 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	49/107 (46%)
		Ion_trans	464..700	CDD:459842	114/263 (43%)
KCNC3	NP_004968.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..87		20/51 (39%)
		Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484	1..78		17/42 (40%)
		Potassium_chann	1..>18	CDD:431870
		BTB_KCNC1_3	89..202	CDD:349721	52/122 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..232		2/21 (10%)
		Ion_trans	289..550	CDD:459842	114/263 (43%)
		Selectivity filter. /evidence=ECO:0000250	503..508		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..613		14/144 (10%)
		PHA03247	<637..752	CDD:223021	27/129 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..746		20/84 (24%)