Protein Alignment Shab and KCNC2

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_631875.1
• Gene: KCNC2 / 3747
• HGNCID: 6234
• Length: 638
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 208/646 - (32%)
• Similarity: 306/646 - (47%)
• Gaps: 124/646 - (19%)

  Fly   306 NSRVSINVGGVRHEVLWRTLERLPHTRLGRLR------ECTT----------------------- 341
            |.||.:||||.|||....||:.||.|||..|.      :|.|
Human     7 NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPPLS 71

  Fly   342 ------HEAIVELC-------DDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSD 393
                  .|.....|       .|:.....|:||||||..|:.:||:|||||||...::|...|.:
Human    72 PGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE 136

  Fly   394 DLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQR---------DEEEFG--------- 440
            :|.:||:||..:|.||...|.|.::      .:||..:.:.         |:|:..
Human   137 ELAFWGIDETDVEPCCWMTYRQHRD------AEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDA 195

  Fly   441 ------EGKCAEY---QKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNT-------LPQ 489
                  :||...:   |..:|.|.|.|.:|.|||.||..|:.||::|.....|.|       ..:
Human   196 AGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNK 260

  Fly   490 LQHIDNGTP-------QDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILP 547
            .:.:.|||.       :.:|.|..||.||:.|||.|:::|...||:|.:|.|..|||||.:||||
Human   261 TEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILP 325

  Fly   548 YFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLML 612
            :::.:.|...:..|.   :||...::|.|.:|||||.||.||..||:.||.|||.|..|..||::
Human   326 FYLEVGLSGLSSKAA---KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 387

  Fly   613 FLAMGVLIFSSLAYFAEK---------DEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKV 668
            |||:|||||:::.|:||:         ..:.|:|.:||..||||.:||||:||||:||.|..|.:
Human   388 FLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452

  Fly   669 IGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAF 733
            :|.:|.:.|||.||:|:|:|||||..:|...|.::|..::|:.......:.|..:|....|..|.
Human   453 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMAC 517

  Fly   734 AKSMDLIDVIVDT--GKQTNVV-HPKGKRQSTPNIGRQTLDVQSAPGHNL----SQTDGNSTEGE 791
            ..:..      ||  ||...:: |.:.......:.|.:.   ..:|...|    |.|...:..||
Human   518 NSTQS------DTCLGKDNRLLEHNRSVLSGDDSTGSEP---PLSPPERLPIRRSSTRDKNRRGE 573

  Fly   792 S----TSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAV-PPYSFDNPNARQTS 847
            :    |:|.....:..|..|.|:...:|  :|:....|::.....| .||:...|..|..|
Human   574 TCFLLTTGDYTCASDGGIRKGYEKSRSL--NNIAGLAGNALRLSPVTSPYNSPCPLRRSRS 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	50/149 (34%)
		Ion_trans	464..700	CDD:459842	110/258 (43%)
KCNC2	NP_631875.1	BTB_KCNC2_4	7..166	CDD:349722	53/164 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..93		4/54 (7%)
		Ion_trans	228..484	CDD:459842	110/258 (43%)
		Selectivity filter. /evidence=ECO:0000250	437..442		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..572		5/36 (14%)