Protein Alignment Shab and KCNA7

DIOPT Version :9

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_114092.2
• Gene: KCNA7 / 3743
• HGNCID: 6226
• Length: 456
• Species: Homo sapiens
• Alignment Length: 458
• Identity: 167/458 - (36%)
• Similarity: 237/458 - (51%)
• Gaps: 97/458 - (21%)

  Fly   292 PPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHT------RLGRLRECTTHEAIVELCD 350
            |||        .....|:.:||.|:|.|...|||.|.|.|      |.||.
Human     6 PPP--------CGCCERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRF-------------- 48

  Fly   351 DYSLADNEYFFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYH 414
             |..|..|||||||..||.::|.:|:: |:|.....:.:..|.:::.::|:.
Human    49 -YDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLG------------- 99

  Fly   415 QRKENVHEEMRKEAESLRQRDEEEFGEGKC----------AEYQKYLWELLEKPNTSFAARVIAV 469
                         |.:|.:..|:|    .|          ..:.:.||.|.|.|.:|.||||:||
Human   100 -------------AAALARLREDE----GCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAV 147

  Fly   470 ISILFIVLSTIALTLNTLPQLQHIDNGT---------------------PQDNPQLA------MV 507
            :|:|.|::|.:...|.|||..:...:||                     |.:.|:|.      :|
Human   148 VSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVV 212

  Fly   508 EAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVV 572
            |.:||.||:.|.::|....|.|..|||..:|:||.:|||||||:|......:....|......::
Human   213 ETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAIL 277

  Fly   573 QVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKF 637
            :|.|::|:.||.||:|||.|||.||.|||.|.:|||||:.||.:||::|||..||||.|..|:.|
Human   278 RVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHF 342

  Fly   638 VSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRR 702
            .||||:||||.:|||||||||:.|.|..||::|::|.|.|||.|:||:|:||:||:.||..:...
Human   343 TSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEG 407

  Fly   703 EKA 705
            |:|
Human   408 EEA 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	31/113 (27%)
		BTB_2	309..408	CDD:280393	31/105 (30%)
		Ion_trans	501..700	CDD:278921	102/204 (50%)
		Ion_trans_2	613..696	CDD:285168	49/82 (60%)
KCNA7	NP_114092.2	BTB_2	15..105	CDD:280393	33/130 (25%)
		BTB	15..98	CDD:197585	30/97 (31%)
		Ion_trans	200..404	CDD:278921	102/203 (50%)
		Ion_trans_2	319..398	CDD:285168	47/78 (60%)
		Selectivity filter. /evidence=ECO:0000250	358..363		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820