DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shab and KCNA6

DIOPT Version :9

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_002226.1 Gene:KCNA6 / 3742 HGNCID:6225 Length:529 Species:Homo sapiens


Alignment Length:480 Identity:166/480 - (34%)
Similarity:241/480 - (50%) Gaps:127/480 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   306 NSRVSINVGGVRHEVLWRTLERLPHTRLG----RLRECTTHEAIVELCDDYSLADNEYFFDRHPK 366
            :.|:.||:.|:|.|...|||...|.|.||    |:|             .:....|||||||:..
Human    40 SERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVR-------------FFDPLRNEYFFDRNRP 91

  Fly   367 SFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAES 430
            ||.:||.:|:: |:|.....:.:..|.:::.::                        ::..||.:
Human    92 SFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFY------------------------QLGDEALA 132

  Fly   431 LRQRDEEEFGEGKCAE-------YQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP 488
            ..:.||....||...|       :|:.:|.|.|.|.:|..||.||::|:|.|::|.:...|.|||
Human   133 AFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLP 197

  Fly   489 QLQHID-----NG-----------------------------TPQD-----------------NP 502
            |.: :|     ||                             ||.:                 ..
Human   198 QFR-VDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTD 261

  Fly   503 QLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQD 567
            ...:||.:||.|||.|.::||||.|.|..||:..:|||||:||.|||::|        .|:..|.
Human   262 PFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITL--------GTELVQQ 318

  Fly   568 VRR------------------VVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFL 614
            ..:                  :::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||
Human   319 QEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFL 383

  Fly   615 AMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVL 679
            .:||::|||..||||.|:.|:.|.|||:.||||.:|||||||||:||.|..||::|::|.|.|||
Human   384 FIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVL 448

  Fly   680 VIALPIPIIVNNFAEFYKNQMRREK 704
            .||||:|:||:||..||..:..:|:
Human   449 TIALPVPVIVSNFNYFYHRETEQEE 473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB 309..416 CDD:197585 29/111 (26%)
BTB_2 309..408 CDD:280393 29/103 (28%)
Ion_trans 501..700 CDD:278921 104/216 (48%)
Ion_trans_2 613..696 CDD:285168 50/82 (61%)
KCNA6NP_002226.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
BTB_POZ_KCNA6 41..170 CDD:349714 42/165 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..233 0/22 (0%)
Ion_trans 258..468 CDD:366146 104/217 (48%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 360..373 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 422..427 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..513
PDZ-binding. /evidence=ECO:0000255 527..529
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.