DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shab and KCNA4

DIOPT Version :9

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_002224.1 Gene:KCNA4 / 3739 HGNCID:6222 Length:653 Species:Homo sapiens


Alignment Length:598 Identity:186/598 - (31%)
Similarity:281/598 - (46%) Gaps:125/598 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 SGAGTGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGG 267
            |...:|..:....|..:.|..:|........|:...::...:..:.|| ||.|.|........|.
Human     7 SAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGS-GGSGGGSHHHHQSRGA 70

  Fly   268 VPTHSQSNTTGALQRTHSRS--------MSSIPPPEPFMIAQSK--------------------- 303
            ..:|...::.|:.:|...||        .||.|.....|.:.|:                     
Human    71 CTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEE 135

  Fly   304 --------------------------------AVN-----SRVSINVGGVRHEVLWRTLERLPHT 331
                                            :|.     .||.|||.|:|.|...:||.:.|.|
Human   136 EEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPET 200

  Fly   332 RLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDL 395
            .||...:.|.:         :....|||||||:..||.:||.:|:: |:|.....:....|::::
Human   201 LLGDPEKRTQY---------FDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEV 256

  Fly   396 EYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNT 460
                            |::|..|....:.|::...:|:.::....|.   |::|.:|.|.|.|.:
Human   257 ----------------KFYQLGEEALLKFREDEGFVREEEDRALPEN---EFKKQIWLLFEYPES 302

  Fly   461 SFAARVIAVISILFIVLSTIALTLNTLPQLQ------------------------HIDN-GTPQD 500
            |..||.||::|:|.|::|.:...|.|||:.:                        |::| |....
Human   303 SSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIF 367

  Fly   501 NPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSL--FLLETNKNATD 563
            |....:||.|||.||:.|:::|..|.|.:..|||..:||||:::|||||::|  .|.:.......
Human   368 NDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNG 432

  Fly   564 QFQDVR--RVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAY 626
            |.|...  .::::.|::|:.||.||:|||.|||.||.|||.|.:|||||:.||.:||::|||..|
Human   433 QQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVY 497

  Fly   627 FAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNN 691
            |||.||..|.|.|||:.||||.:|||||||||:.|.|..||::|::|.|.|||.||||:|:||:|
Human   498 FAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSN 562

  Fly   692 FAEFYKNQMRREK 704
            |..||..:...|:
Human   563 FNYFYHRETENEE 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB 309..416 CDD:197585 30/107 (28%)
BTB_2 309..408 CDD:280393 29/99 (29%)
Ion_trans 501..700 CDD:278921 103/202 (51%)
Ion_trans_2 613..696 CDD:285168 50/82 (61%)
KCNA4NP_002224.1 K_channel_TID 1..>37 CDD:400339 5/29 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..148 20/124 (16%)
BTB_POZ 176..303 CDD:365784 42/154 (27%)
Ion_trans 306..570 CDD:395416 118/263 (45%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 462..475 8/12 (67%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 524..529 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..653
PDZ-binding. /evidence=ECO:0000250 651..653
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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