DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Shaw

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	686	Identity:	216/686 - (31%)
Similarity:	320/686 - (46%)	Gaps:	146/686 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 MSSIPPP-EPFMIAQSKAVN----SRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVE 347
            |:.||.. :.:..|....:|    :||.:||||:|||....||:::|.|||.||.|...
  Fly     1 MTYIPKKMQHYAHAAMNLINMDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALA------ 59

  Fly   348 LCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHK 412
               :|....|||||||||..|:.:||:|||||||...::|...|.::||:||:|...:|.||...
  Fly    60 ---NYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMT 121

  Fly   413 YHQRKE-----------NVHEEMRKEAESLRQRD-EEEFGEGKCAEYQKY---LWELLEKPNTSF 462
            |.|.::           ::..|...|.|..|:.. ||::.:|..:.:|:.   :|.|.::|.:|.
  Fly   122 YTQHRDTQETLAVLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSN 186

  Fly   463 AARVIAVISILFIVLSTIALTLNTLPQLQ---------HIDNGT-------PQDNPQLAM--VEA 509
            ||:.|.|:|:.||.:|.::..|.|.|.::         ...||:       .|.|..:|.  :|.
  Fly   187 AAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIEC 251

  Fly   510 VCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFL------LETNKNATDQFQDV 568
            ||..|||.|.::||.:||:||:|.|..:||||.:|.|.:::.|.|      ||   ||.
  Fly   252 VCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLE---NAD------ 307

  Fly   569 RRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEK 633
              :::.|.|:||:|:.||.|||:||:.|..|.|.|.|||.||:.||.:|::||:||.|:||:.:.
  Fly   308 --ILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQP 370

  Fly   634 D--TKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFY 696
            :  ..|.|||...|||.:|||||||||:.|.|.:|..:|.:|.:.|||.||||:|:||:|||.:|
  Fly   371 NPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435

  Fly   697 KNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQS 761
            .:...|.|..|:|.                                     :...|..|:..|
  Fly   436 SHTQARAKLPKKRR-------------------------------------RVLPVEQPRQPR-- 461

  Fly   762 TPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGS 826
                      :..|||         ...|..|.|..|            |...:.:.....||.:
  Fly   462 ----------LPGAPG---------GVSGCGTPGSGP------------HSGPMGSGGTGPRRMN 495

  Fly   827 SSEQDAVPPYS----FDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAP-NGN 886
            :..:|.|.|.|    |..|.......|:..:......||...:...|.::..........| :..
  Fly   496 NKTKDLVSPKSVAQLFAGPLGASIVAMSPRTMLDLNPALAMGKPTFQPRIPTPLAATPPPPVSSA 560

  Fly   887 GGATGGGVANNLAMVAASSAATA-----VATATNAS 917
            ||.|..|:....|..|.|:...|     :|.:|.||
  Fly   561 GGMTASGIGTTSATGATSAPQPATPLPSIAVSTTAS 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	48/106 (45%)
		BTB_2	309..408	CDD:280393	45/98 (46%)
		Ion_trans	501..700	CDD:278921	95/208 (46%)
		Ion_trans_2	613..696	CDD:285168	44/84 (52%)
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	48/106 (45%)
		BTB_2	27..117	CDD:280393	45/98 (46%)
		Ion_trans	244..439	CDD:278921	94/205 (46%)
		Ion_trans_2	355..429	CDD:285168	37/73 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
	5	4.920