DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shab and kcnd3

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	XP_005167059.1	Gene:	kcnd3 / 327415	ZFINID:	ZDB-GENE-030131-5626	Length:	650	Species:	Danio rerio

Alignment Length:	621	Identity:	194/621 - (31%)
Similarity:	306/621 - (49%)	Gaps:	104/621 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 MSSIPPPEPFMIAQS---KAVNSRVSINVGGVRHEVLWR-TLERLPHTRLGRL-RECTTHEAIVE 347
            ::::|.|    :|.|   |..:..:.:||.|.|.:. || ||:|.|.|.||.. :|...:|
Zfish    22 VANLPMP----VAPSNKNKRQDELIILNVSGRRFQT-WRNTLDRYPDTLLGSSEKEFFFNE---- 77

  Fly   348 LCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHK 412
                   ...||||||.|..|.||||||||||||.....|:.|:.::|.::|:....:..||..:
Zfish    78 -------ETREYFFDRDPDVFRSILNFYRTGKLHYPRYECISAYDEELAFFGIIPEIISDCCYEE 135

  Fly   413 YHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAE--YQKYLWELLEKPNTSFAARVIAVISILFI 475
            |..||       |:..|.|.. |.|:..:.|...  :::.:|...|.|:||..|.|...::..||
Zfish   136 YKDRK-------RENTERLMD-DLEDNKDSKLPNMTFRETMWRAFENPHTSTMALVFYYVTGFFI 192

  Fly   476 VLSTIALTLNTLPQLQHIDNGTPQDNP-------QLAMVEAVCITWFTLEYILRFSASPDKWKFF 533
            .||.|...:.|:| ..::.|  .:|.|       ....::..|:..||:||::|..|:|.:::|.
Zfish   193 ALSVITNVVETVP-CGYMPN--QRDVPCGERYTEAFFCMDTACVMIFTVEYLMRLFAAPSRYRFM 254

  Fly   534 KGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGF 598
            :..::|||::|||||::.|.:  ||.      :||.......|:.|:.||.|.:|||.||:.||:
Zfish   255 RSVMSIIDVVAILPYYIGLVM--TNN------EDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGY 311

  Fly   599 TLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTT 663
            ||::...|||.|:..|.|.::||:::.::|||....:||.|||.:||:..:||||:||||:.|.|
Zfish   312 TLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSSSKFTSIPASFWYTIVTMTTLGYGDMVPKT 376

  Fly   664 ALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMR-----REKALKRREALDRAKREGSIVS 723
            ..||:.|::|.:.||||||||:|:||:||:..|....|     .:|..|.|.|..|..:.||..:
Zfish   377 IAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQKVQKARLARMRISKSGSSTA 441

  Fly   724 FHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLS------- 781
            |.| :.::...:|::|..:.....|    :.|:|..:....:.:.|..::|...|.|.
Zfish   442 FLH-SKRNGLNQSLELTQLPYYKMK----LSPQGSLEEDQQLKKTTSLLESQHHHLLHCLEKTTN 501

  Fly   782 --------------QTDGNSTEGESTS-GRNPATTGTGCYK-------------NYDHVANLRN- 817
                          ||...:...:|.| ......|||.|.:             .:.|..||:.
Zfish   502 HEFVDERLYEQGYLQTALQNFPSQSPSLSSEEGITGTCCSRRPKKNIQPLNATHTHSHTHNLQEL 566

  Fly   818 SNLHNRRGSSSEQDAVPPYSFDNPNARQTSMMAMES 853
            |.||.:.|   ||..:      |.:....::|:.||
Zfish   567 SALHIQCG---EQQPL------NTSRSSLNLMSDES 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	42/108 (39%)
		BTB_2	309..408	CDD:280393	39/100 (39%)
		Ion_trans	501..700	CDD:278921	83/205 (40%)
		Ion_trans_2	613..696	CDD:285168	41/82 (50%)
kcnd3	XP_005167059.1	Shal-type	3..28	CDD:288455	1/5 (20%)
		BTB	42..139	CDD:197585	42/108 (39%)
		BTB_2	42..131	CDD:280393	39/100 (39%)
		Ion_trans	213..411	CDD:278921	84/205 (41%)
		Ion_trans_2	327..407	CDD:285168	41/79 (52%)
		DUF3399	443..556	CDD:288712	18/117 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910